APPLICATION OF THE METHOD OF RANDOM BALANCE TO STUDY THE EFFECT OF THE AMOUNTS OF EXCIPIENTS ON THE TECHNOLOGICAL PARAMETERS OF TABLETS WITH LYOPHILIZED POWDER OF DRONE BROOD HOMOGENATE

Authors

DOI:

https://doi.org/10.11603/2312-0967.2022.1.13056

Keywords:

drone brood, design of experiment, tablets, excipients

Abstract

The aim of the work. Study of the influence of excipients on the pharmaco-technological parameters of powder masses and tablets based on lyophilized drone brood homogenate powder in order to develop the composition of tablets.

Materials and Methods. Active pharmaceutical ingredient – lyophilized drone brood homogenate powder, as well as excipients such as Prosolv SMCC 90, МСС 102, Ludipress, Emdex dextrates, sodium carboxymethyl starch, Neusilin US 2, Neusilin UFL, calcium phosphate dibasic, sodium lauryl sulfate, calcium stearate, citric acid. Tablets were obtained by direct compression. Studies of the effect of excipients on the pharmaco-technological parameters of powder masses and tablets were carried out in accordance with the methods regulated by the State Pharmacopoeia of Ukraine.

Results and Discussion. Studies have shown that close in value were the reviews on bulk density, compression of tablets and their average weight. Given that the results obtained in the study of the angle of natural slope of the powder masses, the homogeneity of the mass of the tablets, the tabletʼs hardness, abrasion and disintegration time, were different, according to these reviews built scattering diagrams.

Conclusions. The application of the random balance method allowed to determine the most significant quantitative factors and stabilize them at optimal levels in the developed tablets with lyophilized drone brood homogenate powder in order to ensure quality in accordance with the requirements of the State Pharmacopoeia of Ukraine.

Author Biographies

B. V. Pavliuk, I. Horbachevsky Ternopil National Medical University

PhD (Pharmacy), Assistant of the Department of Pharmacy Management, Economics and Technology

M. B. Chubka, I. Horbachevsky Ternopil National Medical University

PhD (Pharmacy), Associate Professor, Department of Pharmacy, Faculty of Postgraduate Education

T. A. Hroshovyi, I. Horbachevsky Ternopil National Medical University

DSс (Pharmacy), Professor, Head of the Department of Pharmacy Management, Economics and Technology

M. M. Dobrynchuk, I. Horbachevsky Ternopil National Medical University

M (Pharmacy), the Pharmacy Management, Economics and Technology Department

References

Sawczuk R, Karpinska J, Miltyk W. What do we need to know about drone brood homogenate and what is known, Journal of Ethnopharmacology [serial online]. 2019;245: 111581. DOI: 10.1016/j.jep.2018.10.042

Tikhonov OI, Yarnykh TG, Tikhonova SO, Bashura OG, Shpychak OS, Bondarenko LO, et al. Technology of manufacturing extemporaneous drugs and their use in pharmacy, medicine and cosmetology: guidelines. [Технологія виготовлення екстемпоральних лікарських апіпрепаратів і їх застосування в фармації, медицині та косметології: метод. рек.] Kharkiv; 2016. Ukrainian.

Tikhonov ОI, Bogdan NS, Shpychak OS. Perspective towards the creation “Alternative medical maintenance the population of extemporaneous preparations of bee products”. Zb. Nauk. Pratsʹ spivrob. NMAPO P.L. Shupyka. 2014;23(3): 429-33. Ukrainian

Ishmuratova NM, Ismagilova AF, YAkovleva MP, Tolstikov GA. The unknown about the “royal substance” of honey bees. Fact. Exp. Evol. Organ. 2008;2: 317-20.

Isidorov VA, Bakier S, Stocki M. GC-MS investigation of the chemical composition of honey bee drone and queen larva homogenate. J. Apic. Sci. 2016;60(1): 33-8.

Barnutiu LI, Marghita¸s LA, Dezmirean D, Bobi¸s O, Mihai C, Pavel C. Physico-chemical composition of apilarnil (bee drone larvae). Lucrări Ştiinţifice-Seria Zootehnie. 2013;59: 199-02

Lazaryan DS. Comparative amino acids analysis of bee bread. Pharm Chem J. 2002;36: 680-2.

Sidor E, Dżugan M. Drone brood homogenate as natural remedy for treating health care problem: A scientific and practical approach. Molecules. 2020;25(23): 56-99. DOI: 10.3390/molecules25235699.

Kruszewski MA, Naumowicz M. The importance of the honey bee (Apis mellifera) and bee products in human life. Edu Biol Srodowiskowa. 2017;3: 47-53.

Pavliuk B, Stechyshyn I, Chubka M. Hroshovyi T. Preclinical safety evaluation of drone brood homogenate and justification of pharmacological action. B et al. Pharmacia. 2021;68(4):771-7.

Ghosh S, Sohn HY, Pyo SJ, Jensen AB, Meyer-RochowVB, Jung C. Nutritional composition of Apis mellifera Drones from Korea and Denmark as a potential sustainable alternative food source: Comparison between developmental stages. Foods. 2020;9: 389.

Sampat Ghosh, Chuleui Jung, Victor Benno Meyer-Rochow. Nutritional value and chemical composition of larvae, pupae, and adults of worker honey bee, Apis mellifera ligustica as a sustainable food source. Journal of Asia-Pacific Entomology. 2016;19(2): 487-95. DOI: 10.1016/j.aspen.2016.03.008.49,

Hroshovyi TA, Dobrynchuk MM, Pavliuk BV, Chubka MB. Drone brood – as a raw material for the manufacture of medicines and dietary supplements. Sciences of Europe. 2021;63(2): 36-9.

Hroshovyi TA, Pavlyuk BV, Chubka MB, Stechyshyn SP, Dobrynchuk MM. [Investigation of the influence of the nature of excipients on the quality indicators of tablets with lyophilized drone homogenate powder]. Farmats chasop. 2021;57(1): 40-9. Ukrainian.

State Pharmacopoeia of Ukraine: in 3 volumes. [Державна Фармакопея України: в 3 т.] Kharkiv: State Enterprise "Ukrainian Scientific Pharmacopoeial Center for Quality of Medicines". Ukrainian.

Hroshovyi TA. Mathematical planning of the experiment in conducting research in pharmacy. [Математичне планування експерименту при проведенні наукових досліджень у фармації] Ternopil: TSMU "Ukrmedknyha"; 2008. Ukrainian.

Downloads

Published

2022-06-28

How to Cite

Pavliuk, B. V., Chubka, M. B., Hroshovyi, T. A., & Dobrynchuk, M. M. (2022). APPLICATION OF THE METHOD OF RANDOM BALANCE TO STUDY THE EFFECT OF THE AMOUNTS OF EXCIPIENTS ON THE TECHNOLOGICAL PARAMETERS OF TABLETS WITH LYOPHILIZED POWDER OF DRONE BROOD HOMOGENATE. Pharmaceutical Review Farmacevtičnij časopis, (1), 58–65. https://doi.org/10.11603/2312-0967.2022.1.13056

Issue

No. 1 (2022)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

License

Copyright (c) 2022 Pharmaceutical Review / Farmacevtičnij časopis

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

The authors who publish their materials in this journal agree with the following terms:

  • Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal Результат пошуку зображень за запитом "CC-BY logo".
  • Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.

Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).