STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF IBUPROFEN ESTERS IN COMBINATION WITH LOW-FREQUENCY ULTRASOUND ON THE CARRAGINAN INFLAMMATION MODEL
DOI:
https://doi.org/10.11603/2312-0967.2021.4.12635Keywords:
ibuprofen, ibuprofen esters, low-frequency ultrasound, carrageenan, anti-inflammatory activityAbstract
The aim of the work. Study of the anti-inflammatory activity of the ointment with ibuprofen esters in combination with low-frequency ultrasound.
Materials and Methods. The anti-inflammatory effect of the synthesized compounds was evaluated in a model of carrageenan inflammation by subplantar injection of a carrageenan solution into the hind limb of rats. Low-frequency ultrasound with a frequency of 20-25 kHz was used to enhance skin permeability. The study used white male Wistar rats weighing 180–220 g. The dynamics of changes in the inflammatory process was determined by measuring the thickness and volume of the affected limbs. A 5 % ibuprofen ointment "Dolgit cream" was used as a reference drug. Statistical indicators were calculated using the Microsoft Excel software package.
Results and Discussion. According to the results of the study of the volume of the affected limbs, it was found that starting from the 4th day of treatment, ibuprofen ethyl ester in combination with low-frequency ultrasound demonstrates better anti-inflammatory activity than the reference drug. A similar trend is observed when determining the thickness of the affected limb. Іn the group treated with ibuprofen ethyl ether, the thickness of the affected limbs reaches the physiological norm on the 6th day of treatment, while in the group treated with ibuprofen hexadecyl ether – on the 7th day.
Conclusions. The results obtained indicate that the use of synthesized ibuprofen esters in combination with low-frequency ultrasound leads to an increase in their anti-inflammatory activity. The best dynamics of anti-inflammatory activity is inherent in ibuprofen ethyl ester.
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