TALL BUTTERCUP (Ranunculus acris L.): ANALYTICAL REVIEW OF DISTRIBUTION, CHEMICAL COMPOSITION, BIOLOGICAL ACTIVITY AND MEDICAL APPLICATION
DOI:
https://doi.org/10.11603/2312-0967.2021.3.12476Keywords:
Ranunculaceae, Ranunculus acris, biologically active substances, pharmacological actionAbstract
The aim of the work. Analysis and synthesis of data on the distribution, content of biologically active compounds and the spectrum of use in pharmacy and medicine of tall buttercup (Ranunculus acris L.).
Materials and Methods. Analysis of sources of scientific information on the distribution, chemical composition, pharmacological activity and possible use of tall buttercup (Ranunculus acris L.).
Results and Discussion. Tall buttercup (Ranunculus acris L.) is a perennial herbaceous plant of the Ranunculaceae family, which is common in Ukraine in the wild nature. The plant is unofficial. It is widely used in folk medicine of different countries as antibacterial, antiviral, antitoxic, epithelializing and anti-tuberculosis medicine. The main biologically active substances of this plant are alkaloids (0.1%), tannins (over 2%), γ-lactones (ranunculin, anemonin, protoanemonin), saponins, flavonoids (kaempferol, quercetin), tannins and cardiac glycosides.
Conclusions. Given the significant experience of using Ranunculus acris in folk medicine and data from experimental studies of the content of biologically active substances and a fairly wide range of pharmacological activity, its aboveground organs can be considered as a promising raw material for research in pharmacy for production and production phytopreparations.
References
Kharchenko TA. Narodni ta netradytsiyni metody likuvannya: mif chy realʹnistʹ? Ukrayinsʹkyy medychnyy chasopys [Internet]. 2012 Mar [cited 15.10.2021]; р. 1-3. Available from: URL: https://www.umj.com.ua/article/29431/narodni-ta-netradicijni-metodi-likuvannya-mif-chi-realnist
Nazim M, Mehdiyeva NP, Lyle EC. Medicinal Plants Used in Traditional Medicine of the Caucasus and North America. Journal of Medicinally Active Plants. 2015;4(3):42-66.
Krivosheyeva YeM,Fefelova YeV, Kokhan ST. Spektr farmakologicheskoy aktivnosti rastitel'nykh adaptogenov. Fundamental'nyye issledovaniya. 2011;6:85-89.
.Nikolayeva IG. Razrabotka i standartizatsiya sredstv rastitel'nogo proiskhozhdeniya, obladayushchikh adaptogennoy aktivnost'yu: Avtoref. dis dok. farmt.nauk. Ulan-Ude, 2012. 48 p.
Ernst EJ. Informing the public responsibly about herbal medicine. Diet Suppl. 2009; 6(1): 9-12.
Sambukova TV, Ovchinnikov BV, Ganapol's'kiy VP, et al. Perspektivy ispol'zovaniya fitopreparatov v sovremennoy farmakologii. Farmakologiya. 2017;2:56-63.
Luk'yanchuk AV, Khropot OS, Konechna RT, Kurka MS, Novikov VP, Yasitska-misyak I, Vechorek PP. Doslidzhennya vmistu fenolʹnykh spoluk Anemona nemorosa. Suchasni dosyahnennya farmatsevtychnoyi tekhnolohiyi i biotekhnolohiyi.2017;3:171-3.
Khropot OS, Konechnyy YuT, Kolb YuI, Konechna RT, Hubytsʹka II, Holota S, et al. Vyvchennya hostroyi toksychnosti ta protyzapalʹnoyi aktyvnosti spyrtovykh ekstraktiv travy snu biloho (Pulsatilla alba). Farmatsevtychnyy chasopys. 2019;2(50):60-6
Khropot O, Konechnyi Y, Polish N, Konechna R, Bazavluk Y, Kornіychuk O, Novikov V. The study of the composition of chloroform fraction of Anemone nemorosa L. French-Ukrainian Journal of Chemistry. 2020;7(2):153-9.
Fritz H, et al. Ranunculaceae. In: Anatomic Atlas of Aquatic and Wetland Plant Stems. Springer: Cham;2020. 487 p.
Tianpeng Yin; Le Cai, Zhongtao Ding. A systematic review on the chemical constituents of the genus Consolida (Ranunculaceae) and their biological activities. RSC Advances. 2020[cited 15.09.2021];10. Available from: URL: https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06811j
Lyakh VR, Konechna RT. Prykladni aspekty zastosuvannya likarsʹkykh roslyn rodyny Ranunculaceae v etnomedytsyni ta farmatsiyi. Challenges and achievements of medical science and education. Riga: «Baltija Publishing»; 2020. р. 203-217.
Minarchenko VM. Likarsʹki sudynni roslyny Ukrayiny (medychne ta resursne znachennya). Kyyiv: Fitosotsiotsentr; 2005. 323р.
Shanaida MI. Vmist karbonovykh kyslot u nasinni Nigella sativa ta N. damascena. Ukrayinsʹkyy biofarmatsevtychnyy zhurnal. 2019;3(60):71-6.
Akkol E. K., Süntar I., Erdoğan T. F., Keleş H., Gonenç T. M., Kıvçak B. Wound healing and anti-inflammatory properties of Ranunculus pedatus and Ranunculus constantinapolitanus: a comparative study. Journal of ethnopharmacology [Internet]. 2012 [cited 15.09.2021];139(2):478-84. Available from: https://doi.org/10.1016/j.jep.2011.11.037(2012).
Deghima A, Righi N, Rosales-Conrado N, León-González ME, Baali F, Gómez-Mejía E, et al. Anti-inflammatory activity of ethyl acetate and n-butanol extracts from Ranunculus macrophyllus Desf. and their phenolic profile. Journal of ethnopharmacology [Internet]. 2021 Jan [cited 15.09.2021]; 265:1-9. Available from: https://doi.org/10.1016/j.jep.2020.113347.
Khan FA, Zahoor M, Khan E. Chemical and biological evaluation of Ranunculus muricatus. Pakistan journal of pharmaceutical sciences. 2016;29(2):503-10.
Marrelli M, De Marco CT, Statti G, Neag TA, Toma CC, Conforti F. Ranunculus species suppress nitric oxide production in LPS-stimulated RAW 264.7 macrophages. Natural product research [Internet]. 2021May [cited 15.09.2021]:1-5. Available from: https://doi.org/10.1080/14786419.2021.1920018
Pavlov NV. Rastitel'noye syr'yo Kazakhstana. Moskva, 1997. 551 p.
Narodnaya meditsina Sredney Azii i Kazakhstana. In: Ogudin V. Moskva: Ganga; 2021. 538 p.
Tsewang. J. Tsarong. Tibetan Medicinal Plants. Tibetan Medical Publications, 1995. 132 р.
Aralbay NK, Orakova AK. O lechebnyye svoystvakh Lyutikov (Ranunculus L) Kazakhstana. Bulletin d'EUROTALENT-FIDJIP. 2014;6:80-3.
Ekoflora Ukrayiny. In: Yа. P. Didukh editor. 2nd ed. Kyiv: Fitosotsiotsentr; 2004. p.480.
Popay AI, Edmonds D, Lytile LA, Phung HT. Chemical control of giant buttercup (Ranunculus acris L.). New Zealand Journal of Agricultural Research. 1999;32(2):299-303.
Margaret Grieve. Modern Herbal. London : Stone Basin Books, 2015- 1018p.
Warburg EF, Tutin TG, Clapham AR. Flora of the British Isles. 3rd еdition Cambridge : Cambridge University Press, 1992. 1236 р.
Poisonous . Plants and Animals/ Altmann. H.; transl. and edited by Gwynne Vevers. – London: Chatto and Windus, 1985. 143 p.
Andrew Chevallier. Encyclopedia of Herbal Medicine. London: Dorling Kindersley, 2016. 336 р.
Elias T, Dykeman P. A North American Field Guide to Over 200 Natural Foods. New York: Sterling Publishing, 2009. 288 p.
Facciola S. Cornucopia: A Source Book of Edible Plants. California: Kampong Publications, 1990. 677 р.
Ukrainian Biodiversity Information Network. URL: http://www.ukrbin.com/
Verzilin V, Dedov A, Korzhov S. Yadovityye i karantinnyye rasteniya agrotsenozov. Moskva: Lit-res; 2021. 128 p.
Kelemen CD, Houdkova M, Urbanova K, Badarau S, Gurean D, Pamfil D, et al. Chemical Composition of the Essential Oils of Aerial Parts of Aconitum, Anemone and Ranunculus (Ranunculaceae) Species from Romania. Journal of Essential Oil Bearing Plants. 2019;22(3);728-745.
Bandyakova VA, Macekas A, Svirmickas G, Kadziauskiene K. Amino acid composition of pollen of some nectariferous plants. Khimiya Prirodnykh Soedinenii. 1988;4:610-1.
Scott MG, Peterson RL. Publication. The root endodermis in Ranunculus acris. Histochemistry of the endodermis and the synthesis of phenolic compounds in roots. Canadian Journal of Botany, 19;57(9):1063-77.
Chechetkin IR, Blufard AS, Yarin AY, Fedina EO, Khairutdinov BI, Grechkin AN. Detection and identification of complex oxylipins in meadow buttercup (Ranunculus acris) leaves.. Phytochemistry. 2019 Jan; 157:92-102.
Hamel PB, Chiltoskey MU. Cherokee Plants and Their Uses: A 400 Year History. Cherokee: Cherokee Publications,2002. 71 р.
Pospolite rośliny środkowej Europy F. Činčura i inne. Warszawa: Państwowe Wydawnictwo Rolnicze i Leśne,1990. 90 p.
European Patent Office [Internet]. Available from: URL: https://worldwide.espacenet.com/
Hrodzynsʹkyy A. M. Likarsʹki roslyny: Entsyklopedychnyy dovidnyk. Kyyiv: «Ukrayinsʹka entsyklopediya» im. M. P. Bazhana; 1992. 162 р.
F. Stary, Z. Berger. Poisonous Plants .London: Magna Books,1995. 82 р.
D. Frohne and H. J. Pfänder. A colour atlas of poisonous plants / Translated by N. G. Bisset. London: Wolfe, 1985. 291 p.
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