SCIENTIFIC JUSTIFICATION OF THE APPLICATION OF BURDOCK WITH MODERN MEDICINE AND ANALYSIS OF THE PHARMACEUTICAL MARKET OF MEDICINES ON ITS BASIS
DOI:
https://doi.org/10.11603/2312-0967.2021.2.12178Keywords:
burdock, composition, analysis of the range in Ukraine, pharmacotherapeutic actionAbstract
The aim of the work. The analysis of the pharmaceutical market and determination of the feasibility of substances based on burdock raw material with diverse actions preparation, in particular, in pharmaceutical conditions.
Materials and Methods. Based on bibliosemantic, analytical and logical research methods in the analysis of literature sources, the feasibility of using burdock raw material in the development of original drugs due to the presence of active substances with a broad spectrum of action was determined.
Results and Discussion. As a result of marketing analysis of the pharmaceutical market of Ukraine, it was determined that there are three drugs from the roots of burdock – Detoxiphyte and Nephrophyte in the form of complex species and Alloton in the form of a solution for external use, as well as 5 dietary supplements, including 1 in the form of tablets and 4 – herbal teas for oral application. Cosmetics are presented in the form of hair shampoos (6 positions), hair masks, conditioner, oil extract, face cream (1 offer). Manufacturers are Ukraine (4 remedies), Poland, Italy and France – 2 remedies each.
Folk medicine widely uses decoction, infusion, tincture, oil solutions, ointments, herbal creams, dry root powder, fresh and dried leaves and seeds of burdock in arthritis, rheumatism, psoriasis, wounds, tumors, gout, to improve hair condition and trophism scalp; fight against alopecia and dry seborrhea, showing anti-inflammatory, antispasmodic, multivitamin, tonic, antibacterial, immunostimulatory and antifungal action; it also improves metabolic processes in the body.
Conclusions. Given the sufficient raw material base of burdock, a wide range of pharmacological action of its substances, with the poor range of drugs based on it in the pharmaceutical market, it was determined the feasibility of making original remedies of different directions from raw material of burdock, including pharmaceutical compounding.
References
Singh J, Cumming E, Manoharan G, Kalasz H, Adeghate E. Medicinal chemistry of the anti-diabetic effects of Momordica charantia: active constituents and modes of actions. Open Med. Chem. J. 2011;5(2):70-7. DOI: 10.2174/1874104501105010070
D`yakova NA. [Development and validation of an express method for the isolation and quantitative determination of water-soluble polysaccharides in the leaves of burdock (Arctium lappa L.)]. Khim. rastit. syr'ya. 2018;4:81-7. Russian.
Ryzhskaya V. 100 samykh populyarnykh lechebnykh rasteniy [100 most popular medicinal plants]. Donetsk: Multipress; 2010. Russian.
Galkin OYu, Kotov AG. [Pharmacognostic study and standardization of burdock roots (Arctium lappa L.)]. Ukr. med. al`man. 2011;14(1);55-57. Ukrainian.
Sokolova PD. Rastitel'nyye resursy SSSR: Tsvetkovyye rasteniya, ikh khimicheskiy sostav, ispol'zovaniye. Sem. Asteraceae (Compositae) [Plant resources of the USSR: Flowering plants, their chemical composition, use. Sem. Asteraceae (Compositae)]. SPb; 1993. Russian
Karomatov ID. [Burdock, burdock is a promising herbal remedy (Literature review)]. Elektron. nauch. zh. «Biol. i integrat. med.» 2017;5:163-182. Russian.
Popova NV. Lekarstvennyye rasteniya mirovoy flory [Medicinal plants of the world flora]. Kharkiv: SPDFL Mosyakin VN; 2008. 510 p. Russian.
Gentil M, Pereira JV, Sousa YT et al. In vitro evaluation of the antibacterial activity of Arctium lappa as a phytotherapeutic agent used in intracanal dressings. Phytother Res. 2006;20(3):184-6.
Karakovs`ka NYe, Shhokina KG, Drogovoz SM. [Study of androgenic activity of extracts of leaves and roots of burdock]. Ukr. biofarm. zhurn. 2012;4(21):40-3. Ukrainian.
Moxamad MA, Shhokina KG, Drogovoz SM. [Experimental study of the effect of thick extracts of burdock on the course of model hepatitis in rats]. Ukr. biofarm. zhurn. 2012;4(21):44-8. Ukrainian.
Shhokina KG, Byelik GV, Kucenko TO, Semeniv DV. [The effect of thick extracts of burdock on the development of model prostate hyperplasia in rats]. Clin. farm. 2017;2(3):41-5. Ukrainian.
Oproshans`ka TV, Xvorost OP. [Development of technology for obtaining thick extracts of burdock root and leaves]. Problemy ekolohichnoyi ta medychnoyi henetyky i klinichnoyi imunolohiyi : zb. naukovykh pratsʹ. 2012;1(109):355-9. Ukrainian.
Oproshans`ka TV. [Study of the elemental composition of tinctures of burdock root and leaves]. Problemy ekolohichnoyi ta medychnoyi henetyky i klinichnoyi imunolohiyi : zb. naukovykh pratsʹ. 2013;2(109):232-5. Ukrainian.
Oproshans`ka TV. [Study of antimicrobial activity of tinctures of burdock root and leaves]. Problemy ekolohichnoyi ta medychnoyi henetyky i klinichnoyi imunolohiyi : zb. naukovykh pratsʹ. 2013;2(109):258-62. Ukrainian.
Bogacheva NG, Konyayeva YeA, Alent'yeva OG. [Standardization of medicinal raw material of burdock leaves]. Vopros. biol. med. i farm. khim. 2015;7:30-3. Russian.
Shan S,Wink M. Natural lignans from Arctium lappa as antiaging agents in Caenorhabditis elegans. Phytochem. 2015;117:340-50.
Zhao J, Evangelopoulos D, Bhakta S, Gray AI, Seidel V. Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents. J Ethnopharmacol. 2014;155(1):796-800.
Koriem KhMM, Idris ZH, Haron HF, Omar NA, Lazain HS. Therapeutic effect of Arctium lappa in Schistosoma haematobium associated kidney disturbance: biochemical and molecular effects. J Paras Dis. 2016;40(4):1246-54.
European Pharmacopoeia 8.0, vol. 1. Strasbourg: Council of Europe. 2014.
Shvabe V, red. Rybak VI. Rukovodstvo po izgotovleniyu gomeopaticheskikh lekarstv [Homeopathic Medicine Making Guide]. Moskow: Moskovskoye nauchno-meditsinskoye obshchestvo vrachey-gomeopatov. 1967. Russian.
The Japanese Pharmacopoeia 17th Edition; 2016.
Derzhavna Farmakopeya Ukrainy. [State Pharmacopoeia of Ukraine]. Vol. 3. Kharkiv: Derzh. p-vo «Naukovo-ekspertnyy farmakopeynyy tsentr yakosti likarsʹkykh zasobiv», 2014:732. Ukrainian
Derzhavny`j reyestr likars`ky`x zasobiv Ukrayiny` [State Register of Medicines of Ukraine]. [Internet]. 2020. [cited 2021 Jan 15]. Available from: http://www.drlz.kiev.ua Ukrainian.
Kovalenko VM ed. Kompendium 2019 – likars`ki preparaty` [Compendium 2019 – medicines]. Kyiv;MORION. [Internet]. 2019. [cited 2021 Feb 12]. Available from: https://compendium.com.ua Ukrainian.
Cherny`x VP. Farmacevty`chna ency`klopediya [Pharmaceutical encyclopedia]. 2 ed. Kyiv; MORION. 2010. Ukrainian.
Vojcexivs`ka OV, Sy`tar OV, Taran NYu. [Phenolic compounds: diversity, biological activity, prospects of application]. Visn. Xarkivs`k. nacional. agrarn. univer. Ser. Biol. 2015;1(34):104-19. Ukrainian.
Gumenty`k NYa. Pidvy`shhennya produkty`vnosti cy`koriyu ta zmenshennya vtrat koreneplodiv pry` zby`ranni [Increase the productivity of chicory and reduce root crop losses during harvesting]. avtoref. dy`s. na zdob. nauk. stupenya kand. s.-g. nauk: specz. 06.01.09 «Rosly`nny`cztvo». Kyiv. 2004. Ukrainian.
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