THE CHOICE OF STABILIZER OF EXTEMPORANEOUS SUSPENSION WITH BISMUTH NITRATE BASIC

Authors

DOI:

https://doi.org/10.11603/2312-0967.2021.2.12125

Keywords:

suspension, technology, stabilizer, research

Abstract

The aim of the work. The choice of stabilizer of extemporaneous suspension with bismuth nitrate basic, followed by the creation of a drug for use in gastroenterology.

Materials and Methods. The object of the study were samples of extemporal suspension of bismuth nitrate basic made according to traditional rules of preparation of suspensions. Sedimentation stability and resuspendability studies were studied for suspension samples using different stabilizers. Microscopic analysis was performed to determine the particle size and homogeneity of the dispersed phase distribution.

Results and Discussion. The results of the study show that samples of nonstabilized suspension and suspension with the adding of sodium alginate, NaCMC and xanthan gum during storage worsen their resuspension and are characterized by aggregative instability after 14 days of storage. The suspension sample with aerosil is a readily suspended and has satisfactory uniformity characteristics of the active pharmaceutical ingredient particles in the dispersion medium.

Conclusions. The aggregative stability and appearance of suspension samples depending on stabilizers and their shelf life have been studied. A study of the resuspension of stabilized suspension samples was performed and aerosil was selected as a stabilizer of suspension with bismuth nitrate basic for a further research on the development of extemporaneous drug.

Author Biographies

G. M. Melnyk, National University of Pharmacy of the Ministry of Health of Ukraine

PhD (Pharmacy), postdoctoral student of the Technology of Drugs Department

T. G. Yarnykh, National University of Pharmacy of the Ministry of Health of Ukraine

DSc (Pharmacy), professor, Head of the Technology of Drugs Department

G. B. Yuryeva, National University of Pharmacy of the Ministry of Health of Ukraine

PhD (Pharmacy), associate Professor of the Technology of Drugs Department

References

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Published

2021-07-14

How to Cite

Melnyk, G. M., Yarnykh, T. G., & Yuryeva, G. B. . (2021). THE CHOICE OF STABILIZER OF EXTEMPORANEOUS SUSPENSION WITH BISMUTH NITRATE BASIC . Pharmaceutical Review Farmacevtičnij časopis, (2), 14–20. https://doi.org/10.11603/2312-0967.2021.2.12125

Issue

No. 2 (2021)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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