STUDY OF THE INFLUENCE OF THE NATURE OF EXCIPIENTS ON THE QUALITY INDICATORS OF TABLETS WITH LYOPHILIZED DRONE BROOD HOMOGENATE POWDER

Authors

DOI:

https://doi.org/10.11603/2312-0967.2021.1.11940

Keywords:

design of experiment, tablets, lyophilized drone brood

Abstract

The aim of the work. Study of the effect of excipients (DR) on the pharmaco-technological parameters of tablets based on the lyophilized powder of drone brood homogenate in order to develop the composition of tablets.

Materials and Methods. The active pharmaceutical ingredient is a lyophilized powder of drone brood homogenate, as well as excipients, which are divided into 5 groups by functional purpose. The tablets were obtained by direct compression. Study of the influence of excipients on the pharmaco-technological parameters of powder masses and tablets regulated by the State Pharmacopoeia of Ukraine.

Results and Discussion. The research was conducted based on a five-factor experiment based on the Hyper-Graeco-Latin square 5x5. The influence of excipients of different groups, namely, samples of microcrystalline cellulose (МСС), fillers based on sugars, leavening agents, sliding substances (moisture regulators) and lubricants on the process of pressing tablets with lyophilized drone brood homogenate powder has been studied. The results of the study show that the bulk density, the angle of repose, the compression process, the average weight and the uniformity of weight are most affected by sliding substances (moisture regulators). Looseners are decisive in the effect on the disintegration time of tablets. To make a decision on the choice of optimal excipients used generalized indicators – the functions of desirability and usefulness

Conclusions. The effect of 25 excipients on the pharmaco-technological parameters of tablets with lyophilized drone brood homogenate powder was studied. According to the set of studied indicators, the best combinations of excipients were selected in order to further study their impact: Neusilin US 2, Neusilin UFL 2, calcium phosphate dibasic (factor D); sodium starch glycolate and sodium carboxymethyl starch (factor С); sodium lauryl sulfate and calcium stearate (factor Е); Prosolv SMCC 90 and МCC 102 (factor А); Ludipress and Emdex dextrates (factor В).

Author Biographies

T. A. Hroshovyi, I. Horbachevsky Ternopil National Medical University

DSc (Pharmacy), Professor, Head of the Department of Pharmacy Management, Economics and Technology

B. V. Pavliuk, I. Horbachevsky Ternopil National Medical University

PhD, Department of Pharmacy Management, Economics and Technology

M. B. Chubka, I. Horbachevsky Ternopil National Medical University

PhD (Pharmacy), Associate Professor, Department of Pharmacy, Faculty of Postgraduate Education

I. P. Stechyshyn, I. Horbachevsky Ternopil National Medical University

PhD, Department of Pharmacy Management, Economics and Technology, I. Horbachevsky Ternopil National Medical University

M. M. Dobrynchuk, I. Horbachevsky Ternopil National Medical University

student of the Department of Pharmacy Management, Economics and Technology

References

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Published

2021-05-08

How to Cite

Hroshovyi, T. A., Pavliuk, B. V. ., Chubka, M. B., Stechyshyn, I. P., & Dobrynchuk, M. M. (2021). STUDY OF THE INFLUENCE OF THE NATURE OF EXCIPIENTS ON THE QUALITY INDICATORS OF TABLETS WITH LYOPHILIZED DRONE BROOD HOMOGENATE POWDER. Pharmaceutical Review Farmacevtičnij časopis, (1), 40–49. https://doi.org/10.11603/2312-0967.2021.1.11940

Issue

No. 1 (2021)

Section

Pharmaceutical technology, biopharmacy, homeopathy, biotechnology

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