EXPERIMENTAL DESIGN IN RESEARCH AT THE CREATION OF TABLET MEDICINES
DOI:
https://doi.org/10.11603/2312-0967.2021.1.11938Keywords:
experimental design, design quality, tablet medicines, artificial neural networks, modified releaseAbstract
Message 3. Using the artificial neural networks in the design of experiment on the development of composition and technology of tablet medicines with modified release.
The aim of the work. Analysis and systematization of literature data on using the method of artificial neural networks in pharmaco-technological studies of tablet medicines with modified release.
Materials and Methods. The methods of information retrieval and analysis of literature data on using artificial neural networks for the design of the experiment in research to develop the composition and technology of solid dosage forms with modified release are used in the article.
Results and Discussion. The implementation of design quality in pharmaceutical development has stimulated researchers to active using the methods of statistical analysis in the design of the experiment. The development of machine learning methods, in particular artificial neural networks has allowed to apply them actively in the development of the composition and technology of solid dosage forms with modified release, in pharmacokinetic and pharmacodynamic modeling. Examples of using the statistical programs based on artificial neural networks to determine the relationship between independent variables and critical quality indicators of the obtained drugs are considered.
Conclusions. The artificial neural networks programs are excellent tools for the development of composition and technology, as well as for the study of drugs, which not only give accurate results, but also significantly reduce the time required and material resources. The use of statistical programs based on artificial neural networks simplifies the process of creating solid dosage forms with modified release, optimizes the study of their stability and the release of active substances.
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