DEVELOPMENT OF COMPOSITION AND TECHNOLOGY OF GAMMA-AMINOBUTYRIC ACID WITH THIOTRIAZOLINE TABLETS
DOI:
https://doi.org/10.11603/2312-0967.2020.3.11422Keywords:
GABA, thiotriazoline, tablets, neuroprotection, wet granulation methodAbstract
The aim of the work. To develop the composition and technology of gamma-aminobutyric acid with thiotriazoline tablets.
Materials and Methods. We used gamma-aminobutyric acid (Sigma-Aldrich, USA); thiotriazoline (State Enterprise “Chemical Reagents Plant” of the Scientific and Technological Complex of the Institute of Single Crystals of the National Academy of Sciences of Ukraine), excipients of domestic and foreign production. GABA with thiotriazoline tablets were prepared by wet granulation. We compressed the tablets using a laboratory tablet press 6000S (Belarus) with a punch diameter of 10 mm and controlled their pharmaco-technological properties.
Results and Discussions. A third-order Latin square was used to study the three factors. The influence of the nature of excipients on the tablets appearance, the uniformity of mass, the friability, disintegration time and resistance to crushing were studied. Based on the results of experimental studies, the analysis of variance of experimental data was carried out and conclusions were made about the influence of the studied factors on the quality indicators of GABA with thiotriazoline tablets.
Conclusions. Result of the study, the influence of three excipient factors on the appearance, the uniformity of mass, the friability, disintegration time and resistance to crushing of tablets was studied. Analysis of variance of the results allowed to choose the better excipients (MCC 301, 3 % solution of MC 100, magnesium stearate), which provide the pharmacopoeial pharmaco-technological requirements for tablet dosage forms.
References
Mazur IA, Chekman IS, Belenichev IF. Metabolithotropic вrugs. [Метаболитотропные препараты] Zaporozhye; 2007. Russian.
Chernyy VI, Bukhtyyarova NV, Kucherenko LI, Horchakova NA Neuroprotection and neuroplasticity. [Нейропротекция и нейропластичность] Kyiv: Lоhоs; 2015. Russian.
Shnayder N. [The role and place of pharmacological cerebroprotection in the prevention and correction of cognitive impairment: hypotheses and evidence]. Zdorovia Ukrayiny. 2007;3(160): 29-30. Russian.
Kucherenko LI, Khomylova OV, Levykh AE. [The use of neurotransmitter amino acids in modern medicine]. Retsept. 2016;5(19): 616-20. Russian.
Horchakova NA, Belenichev IF, Mazur IA. [The mechanism of antioxidant and anti-ischemic action of thiotriazolin]. Novosti meditsyny i farmatsii. 2007; 2(206): 11-21. Russian.
Mazur IA, Voloshin NA, Chekman IS. Thiotriazoline: pharmacological aspects and clinical usage. [Тіотриазолін: фармакологічні аспекти та клінічне застосування]. Novosti meditsyny i farmatsii; 2005. Russian.
Mazur IA, Chekman IS, Belenichev IF, Kucherenko LI. [The development of medicines based on fixed combinations with antioxidants is a promising area of modern pharmacology]. Farmakol ta likar toksycol. 2011;5: 199-200. Russian.
Khromylova OV. [Choice of excipients to obtain tablets of L-arginine with thiotriazoline by wet granulation. Message 1.] Retsept.. 2018; 4(21): 516-24. Russian.
Kucherenko LI, Khromylova OV. [Choice of excipients to obtain tablets of Isoniazid with Thiotriazolin by wet granulation]. Farmatsevt chasop. 2013;4: 83-7. Ukrainian
Hroshovyi TA, Martsenyuk VP, Kucherenko LI, Vronska LV, Huryeyeva SM. Mathematical planning of experiment in pharmacy. [Математичне планування експерименту при проведенні наукових досліджень в фармації] Ternopil: Ternopil State Medical University; 2008. Ukrainian.
State Enterprise Ukrainian Scientific Pharmacopoeial Center of Medicines Quality. 2nd ed. [Державна Фармакопея України: в 3 т.] Kharkiv: State Enterprise Ukrainian Scientific Pharmacopoeial Center of Medicines Quality; 2015. Ukrainian.
Downloads
Published
How to Cite
Issue
Section
License
The authors who publish their materials in this journal agree with the following terms:
- Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal
. - Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.
Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).
