EXPERIMENTAL DESIGN IN RESEARCH AT THE CREATION OF TABLET MEDICINES
DOI:
https://doi.org/10.11603/2312-0967.2020.2.11204Keywords:
experimental design, quality design, mathematical experiment planning, tablet medicines, quality factors, dispersion analysisAbstract
The aim of the work. Analysis and systematization of literature data on research design using mathematical experiment planning when creating and improving the technology of tablet preparations.
Materials and Methods. The methods of information retrieval, analysis of literature data on the design of the experiment at the stage of studying qualitative factors during research on the creation of tablet medicines were used in the work.
Results and Discussion. The literature data and our own research on the use of mathematical experiment planning in the study of qualitative factors at the stage of development of the composition and technology of tablet medicines are presented in the work. Examples of using plans of Latin, Greek-Latin and hyper-Greek-Latin squares for the study of qualitative factors with the same number of levels are given. Examples of using plans of Latin cubes and parallelepipeds to study qualitative factors with a different number of levels are considered.
Conclusions. Quality design is an important and widely used technique in pharmaceutical development. Experimenters use its methods at different stages of the study – from setting goals to characterizing the finished product. This is especially important in the process of creating and researching tablet medicines, which is multi-stage. The use of mathematical experiment planning at the research planning stage allows you introduce the principle of “quality design” in both scientific and industrial conditions when creating tablet medicines. The examples of conducting research on the study of qualitative factors with the same and different number of levels, methods for constructing plan of dispersion analysis, their statistical analysis and interpretation of the results of experimental studies were presented.
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