THE STUDY OF HYPOLIPIDEMIC EFFECT AT COURSE ASSIGNMENT OF Verbena officinalis L. HERB EXTRACTS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.4.10668

Keywords:

herb, extracts, Verbena officinalis L., lipids, hyperlipidemic effect

Abstract

The aim of the work. Investigation the effect of Verbena officinalis L. herb extracts on the level of lipids in the blood of experimental animals using the model of atherosclerotic hyperlipidemia.

Materials and Methods. The investigation of the effect of Verbena officinalis L. herb extracts on the level of lipid fractions in the blood of experimental white rats was performed using the Triton model of hyperlipidemia. The pharmacotherapeutic efficacy of the investigated extracts was proved on the basis of biochemical, morphological and histological parameters.

Results and Discussion. The received data of biochemical parameters of rats blood indicates that the course using, within 10 days, of standardized Verbena officinalis L. herb extracts by animals with atherosclerotic hyperlipidemia simulated by Triton WR-1339, significantly decrease the level of lipids in it.

Conclusions. The study of the biochemical parameters dynamics in the blood of rats with atherosclerotic hyperlipidemia simulated by Triton WR-1339, at course assignment of Verbena officinalis L. herb extracts indicates that the use of the extracts reduces the level of blood lipids, namely total lipids, β-lipoproteins, triglycerols, total cholesterol, as well as the parameters of total protein, urea, ALT and AST. The most pronounced effect was demonstrated by Verbena officinalis L. water-alcohol extract.

Author Biographies

N. M. Posatska, Ivano-Frankivsk National Medical University

Master of Pharmacy, Assistant of the Organization and Economics Pharmacy and Drug Technology Department

A. R. Grytsyk, Ivano-Frankivsk National Medical University

DS (Pharmacy), Professor, Chief of Pharmacy Department

О. А. Struk, Ivano-Frankivsk National Medical University

PhD (Pharmacy), Associate Professor of the Pharmacy Department

V. M. Ivanochko, Ivano-Frankivsk National Medical University

PhD (Medicine), Associate Professor of the Department of Anatomy

A. O. Klymenko, Ivano-Frankivsk National Medical University

DS (Medicine), Professor of the Medical Chemistry Department named after academician H. O. Babenko

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Published

2019-12-09

How to Cite

Posatska, N. M., Grytsyk, A. R., Struk О. А., Ivanochko, V. M., & Klymenko, A. O. (2019). THE STUDY OF HYPOLIPIDEMIC EFFECT AT COURSE ASSIGNMENT OF Verbena officinalis L. HERB EXTRACTS. Pharmaceutical Review Farmacevtičnij časopis, (4), 57–65. https://doi.org/10.11603/2312-0967.2019.4.10668

Issue

No. 4 (2019)

Section

Pharmacological researches of biologically active substances

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