THE INFLUENCE OF "MELANIZOL" SUPPOSITORIES ON CLINICAL BLOOD INDICES ON NON-SPECIFIC VAGINITIS IN RATS

Authors

DOI:

https://doi.org/10.11603/2312-0967.2019.3.10404

Keywords:

nonspecific vaginitis, metronidazole, tea tree oil, suppositories, clinical indicators of blood

Abstract

The aim of the work. Investigation of the influence of new vaginal suppositories "Melanizol" on clinical blood counts on the background of nonspecific vaginitis in rats.

Materials and methods. Nonspecific vaginitis was modeled by a single intravaginal irritant application (a mixture of turpentine and dimethyl sulfoxide) to non-linear female rats. Vaginal temperature, ESR, leukocyte count and leukocyte blood formula were used as a control indicators of treatment of vaginitis. As reference drug there was taken suppositories of domestic production "Gravagin", recommended for the treatment of nonspecific vaginitis.

Results and discussion. The study found that suppositories "Melanizol" containing metronidazole and tea tree oil, during the treatment of nonspecific vaginitis significantly reduce the temperature in the vagina, the number of leukocytes and ESR in the blood of female rats and restore the indicators of leukocyte formula in comparison with animals of pathology group and with the first day of the study throughout the experiment. This indicates the therapeutic effect of the studied suppositories "Melanizole" in the conditions of experimental nonspecific vaginitis, namely, a decrease in the manifestations of inflammation. It is established that the studied suppositories "Melanizol" effectively reduce the clinical manifestations of vaginitis and significantly exceeding the reference drug "Gravagin".

Conclusions. The results of the experiment allow us to recommend the suppositories "Melanizol" for further study as a drug with anti-inflammatory effect for the treatment of nonspecific vaginitis.

Author Biographies

O. V. Dolzhykova, National University of Pharmacy

PhD (Pharmacy), associate professor of the Clinical Laboratory Diagnostics Department, Kharkiv

L. M. Maloshtan, National University of Pharmacy

DS (Biology), Professor, Chief of Physiology and Human Anatomy Department, Kharkiv

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Published

2019-09-09

How to Cite

Dolzhykova, O. V., & Maloshtan, L. M. (2019). THE INFLUENCE OF "MELANIZOL" SUPPOSITORIES ON CLINICAL BLOOD INDICES ON NON-SPECIFIC VAGINITIS IN RATS. Pharmaceutical Review Farmacevtičnij časopis, (3), 67–73. https://doi.org/10.11603/2312-0967.2019.3.10404

Issue

No. 3 (2019)

Section

Pharmacological researches of biologically active substances

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