EXPERIENCE IN IMPLEMENTATION OF THE NEW EDUCATIONAL DISCIPLINE “PHYSICO-CHEMICAL ANALYSIS IN DRUG DEVELOPMENT” IN THE PROCESS OF TRAINING OF FUTURE PHARMACISTS

Abstract

The basic tasks of the higher school are the training of specialists with profound knowledge in fundamental and applied sciences and are capable to apply obtained knowledge to solve various problems creatively. The new discipline "Physico-chemical analysis in drug development" was introduced into the educational process in 2018–2019 for the third year students of the pharmaceutical faculty. This subject forms in students a holistic view of the drug development and the usage of modern instrumental methods for their analysis. The developed discipline includes a course of lectures, methodical instructions for practical work and preparation for lectures and classes which are located in the Moodle system. The lecture course is presented in the form of multimedia presentations on five topics and covers the methodology of innovative drug development and modern physico-chemical methods of analysis (chromatographic, spectral, magnetic, diffraction and hybrid). The discipline includes seven practical works, which developes the ability of special terminology using, instrumental equipment and allow mastering in practice the knowledge of the theoretical basis of physico-chemical analysis. Lab classes provides core skills in software like PASS, Discovery Studio Visualizer and HyperChem, which are used for molecular modeling and prediction of drug activity. Using IR Tutor application allows students to master interpretation of IR spectra of organic compounds and MestRes – for processing, analysis and representation of nuclear magnetic resonance spectra. Completion of the discipline involves writing a final work, which contains MCQ, theoretical questions and creative task. Students’ self-study based on an elaboration the list of issues which were not rewieved within the lectures and were not discussed within the practical classes, by means of personal information search.