EXPERIENCE IN IMPLEMENTATION OF THE NEW DISCIPLINE “METHODOLOGY OF BIOANALYTICAL RESEARCH” IN TRAINING OF FUTURE MASTERS OF PHARMACY
DOI:
https://doi.org/10.11603/m.2414-5998.2024.3.14961Keywords:
bioanalytical chemistry, methodology, validation, bioequivalence, pharmacokinetics of drugsAbstract
One of the areas of professional activity for students of higher education under the Pharmacy program at TNMU after graduation is work in laboratories for the study of pharmacokinetics and bioequivalence of drugs. A new elective discipline “Methodology of Bioanalytical Research” was introduced into the educational process in the 2022–2023 academic year for the fifth-year students of the Faculty of Pharmacy of full-time and part-time forms of study.
The methodology of bioanalytical research, as a science based on the general laws of chemical sciences, studies the methods of analysis of analytes of various pharmacological groups during preclinical and clinical studies, including bioequivalence and bioavailability studies, as well as in vitro studies in the ADMET category (absorption, distribution, metabolism, excretion and toxicity), which are used in the modern global pharmaceutical industry to develop and improve new drug candidates at an early preclinical stage. The total hours of the discipline is 90 hours: lectures – 6 hours, practical classes – 24 hours and independent work of higher education students – 60 hours. All lectures are accompanied by multimedia data to improve the perception of information in the study of the discipline. During the practical classes, interactive technologies of collective group learning, situational modelling technologies and technologies for processing discussion issues are used to help higher education students understand and master the basic principles of bioanalytical development and its validation in the study of pharmacokinetics and bioequivalence of medicines. In addition, during practical classes and independent work, higher education students master web applets and software resources, including: SwissADME, SwissTarget Prediction, SuperPred, ProTox 3.0, AutoDock 4.2, PyMOL and others.
The knowledge gained by higher education applicants during the study of the elective discipline “Methodology of Bioanalytical Research” will be a key stage in the formation of professional competencies and their implementation in the future professional activities of masters of pharmacy.
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