COMPARATIVE CHARACTERISTICS OF THE CLINICAL EFFICACY OF DIFFERENT TREATMENT REGIMENS IN CHILDREN WITH ATOPIC DERMATITIS, FEATURES OF USING SPECIFIC IMMUNOLOGICAL TOLERANCE INDUCTION.
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7245Keywords:
atopic dermatitis, immune tolerance induction, allergen-specific immunotherapy, probiotics, cellular and humoral immunity.Abstract
The aim of the study – to study the effectiveness and to evaluate perspective of the allergen-specific immunotherapy in combination with prolonged course of probiotics in children with atopic dermatitis as a method of inducing immunological tolerance, to analyse the results of clinical practice experience.
Materials and methods. In the course of the research work all children were examined by general clinical methods such as: assessment of complaints, anamnestic data, objective status of patients with the definition of physical development, general clinical-laboratory and biochemical, immunological, allergological, instrumental methods such as ultrasound of skin and dermatoscopy.
The comparative assessment of effectiveness of traditional therapy and complex treatment of AD with the use of allergen-specific immunotherapy and prolonged course of probiotics in 108 children aged from 4 to 18 were conducted, the control group consisted of 34 children of the same age with patients.
Results and discussion. The article presents the data on the perspectives of application of allergen-specific immunotherapy in combination with probiotics in children with atopic dermatitis, and also the results of research and effectiveness of proposed treatment in children with atopic dermatitis aged 4 to 18 years. The evaluation and comparison of traditional therapy and allergen-specific immunotherapy in combination with probiotics in children with atopic dermatitis were done. Control of quality and efficiency of complex therapy was conducted according to the results of immunogram, namely indicators of cellular and humoral immunity, cytokine status and serum immunoglobulins.
Conclusions. The expediency and prospect of using allergen-specific immunotherapy in combination with prolonged probiotics therapy in children with atopic dermatitis are proved.
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