HYPERALDOSTERONISM – PREVALENCE AND WHERE TO FIND IT
DOI:
https://doi.org/10.11603/2415-8798.2017.1.7553Keywords:
symptomatic complex hyperaldosteronism, hypertension, clinical criteria.Abstract
Hyperaldosteronism is a complex clinical and pathological hormonal metabolic syndrome, which includes symptoms of vascular tone disorders (hypertension), mineral metabolism, renal and neuromuscular disorders caused by excessive unregulated secretion main mineralocorticoid adrenal hormones – aldosterone and mineralocorticoides close to it.
The aim of the study – to review general practitioners, cardiologists, endocrinologists symptom of hyperaldosteronism.
Material and Methods. Analysis of the basic fundamental research to determine the nature and prevalence of hyperaldosteronism in patients with hypertension.
Results and Discussion. It was set the frequency of primary hyperaldosteronism in patients with resistant hypertension according to various statistics from 8 to 15 %. For proper treatment of hyperaldosteronism it is necessary the distribution in corrective surgery and not corrective form. Search criteria of hyperaldosteronism are: concierge poorly controlled hypertension combined with arrhythmia, paresthesia, convulsions, heart pain, headache; hypertension, resistant to antihypertensive therapy for at least three drugs; combination of hypertension with hypopotassiumemia; hypertension in young children, especially under 20 years; hypertension and a family history of early hypertension; hyperaldosteronism in cases of direct family relatives.
Conclusions. Hyperaldosteronism is a complex syndrome, one manifestation of which is resistant hypertension. In 15 % of patients with hypertension is the cause of hyperaldosteronism. In such cases, surgical treatment, removal of aldosteroma is the only effective treatment for hypertension.
References
Funder, J., Carey, R., Fardella, C., Gomez-Sanchez, C., Montero, F., Stowasser, M., … Montori, V. (2008). Case detection, diagnosis and treatment of patients with primary aldosteronism. An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 93, 3266-3281.
Conn, J. (1955). Presidential address. I Painting background. II Primary aldosteronism A new clinical syndrome. J. Lab. Clin. Med., 45, 3–17.
Conn, J. (1964). Plasma rennin activity in primary aldosteronism. Importance in differential diagnosis and in research of essential hypertension. JAMA. 190, 222–225.
Nwanko, T., Yoon, S., Burt, V., & Gu, Q. (2013). Hypertension among adults in US: National Health and Nutrition Examination Survey, 2011–2012. National Center for Health Statistics, 133, 1–8.
Hajjar, I., & Kotchen, T. (2003). Trends in prevalence, awareness, treatment and control of hypertension in United States, 1988–2000. JAMA, 290, 199–206.
Tyler, C., Sung-Sung, Y., Orthis, E. et al. (2012) National surveillance definitions of hypertension prevalence and control among adults. Circ. Cardiovasc. Qual. Outcomes, 5, 343–351.
James, P., Oparil, S., Carter, B., Cushman, W., Dennison-Himmelfarb, C., Handler, J., … Ortiz, E. (2014). 2014 evidence-based guidelines for the management of high blood pressure in adults: report from the panel members appointed to the 8th Joint National Committee. JAMA, 311, 507–520.
Kovalenko, V. N. (Eds.). (2008). Rukovodstvo po kardiologii [Cardiology guidance]. Kyiv : Morion [in Russian].
Eurostat. Eurostat Statistics. Luxembourg: Statistical Office of the European Comission ( 2012).
Shchetinin, V. V., Maistrenko, N. A., & Eqiev, V. N. (2002). Novoobrazovanie nadpochechnikov [Growth of adrenal glands]. Moscow : Medpractika [in Russian].
Kalinin, A. P., Maistrenko, N. A. & Vetshev, P. S. (2004). Khirurgicheskaya endokrinologiya : Rukovodstvo [Surgical Endocrinology Guidelance]. St. Petersburg : Piter [in Russian].
Gordon, R. (1995). Primary aldosteronism. J. Endocrinol. Invest., 18, 495–511.
Ganguli, A. (1998). Primary aldosteronism. New Engl. J. Med., 339, 1828–834.
Gupta, V. (2011). Mineralocorticoid hypertension. Indian J. of Endocrinol. and Metab., 15, 8, 298–312.
Mattsson, C., & Young, W. (2006). Primary aldosteronism: diagnostic and treatment strategies. Nephrology, 2, 198–208.
Young, W. (2007). Primary aldosteronism: renaissance of syndrome. Clin. Endocrinol. (Oxf.), 66, 607–618.
Lukyanchikov, V. S., Kalinin, A. P. & Agaev, R. A. (1991). Giperaldosteronism : metodichiskie rekomendatsii [Hyperaldosteronism : methodical recommendations]. Moscow : Moniki [in Russian].
Amar, L., Ploun, P. F., & Steichen O. (2010). Aldosterone-producing adenoma and other surgiccaly correctable forms of primary aldosteronism. Orphanet. J. of Rare Diseases, 5.
Iacobone, M., Citton, M., Viel, G., Rossi, G., & Nitti, D. (2015). Approach to the surgical management of primary aldosteronism. Gland Surgery, 4, 69–81.
Fishman, L., Kuchel, O., Liddle, J, Michelakis, A., Gordon, R., & Chick, W. (1968). Incidence of primary aldosteronism uncomplicated “essential” hypertension. A prospective study with elevated aldosterone secretion and suppressed plasma rennin activity used as diagnostic criteria. JAMA, 205, 497–502.
Berlund, G., Andersson, O., & Wilhelmen, L. (1976). Prevalence of primary and secondary hypertension: studies in a random population sample. Brit. Med. J., 2, 554–556.
Tucker, R., & Labarth, D. (1977). Frequency of surgical treatment for hypertension in adults at the Mayo clinic from 1973 through 1975. Mayo Clin. Proc., 52, 549–555.
Sinclair, A., Isles, G., Brown, L., Cameron, H., Murray, G., & Robertson, J. (1987). Secondary hypertension in blood pressure clinic. Arch. Int. Med., 147, 1289–1293.
Kaplan, N. (1994). Clinical hypertension. Baltimore: Wilkins & Wilkins.
Conn, J., Knoff, R., & Nesbit, R. (1964). Clinical characteristics of primary aldosteronism from analysis of 145 cases. Am. J. Surg., 107, 159–172.
Conn, J., Cohen, N., Rovner, D. (1964). Suppression of plasma renin activity in primary aldosteronism. JAMA, 190, 213–221.
Mulatero, P., Stowasser, M., Loh, K., Fardella, C., Gordon, R., Mosso, L., & Gomez-Sancher, C. Increased diagnosis of primary aldosteronism including surgically correcrable forms in centers from five countries. J. Clin. Endocrinol. Metab., 89, 1045–1050.
Saydah, S., Franklin, J., & Cowice, C. (2004). Poor control of risk factors for vascular disease among adult with previously diagnosed diabetes. JAMA, 291, 335–342.
Mukherjee, J., Khoo, C., Thai A., Chionh, S., Pin, L., & , K. (2010). Type 2 diabetic patients with resistant hypertension should be screened for primary aldosteronism. Diabetes & Vascular Disease Res., 7, 6–13.
Umpierrez, G., Cantey, P., & Smiley C. (2007). Primary aldosteronism in diabetic subjects with resistant hypertension. Diabetes Care., 30, 1699–1703.
Omura, M., Saito, J., Yamaguchi, K., Karuta, Y., & Nishikawa, T. (2004). Prospective study of the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinivc in Japan. Hypertens. Res, 27, 293–302.
Andersen, G., Toftdahl, D., Lund, J., Strandgaard, S., & Nielsen, P. (1988). The incidence rate of phaeochromocytoma and Conn′s syndrome in Denmark 1977–1981. J. Hum. Hypertens., 2, 187–189.
Takayanagi, R., Miura, K., & Hakagawa, H. (2000). Epidemiologic study of adrenal gland disorders in Japan. Biomed. Pharmacother., 54, 1, 164–168.
Mosso, L., Carvajal, C., González, A., Barraza, A., Avila, F., Montero, J., … Fardella, C.E. (2003). Primary Aldosteronism and Hypertensive Disease. Hypertension., 42, 161–165.
Newton-Chen, C., Guo, C., Gona, P., Larson, M., Benjamin, E., Wang, N., … Vasan, R. (2007). Clinical and genetic correlates of aldosterone – to - renin ratio and relations to blood pressure in a community sample. Hypertension., 49, 846–856.
Calhoun, D. (2006). Aldosteronism and hypertension. Clin. J. Am. Soc. Nephrology., 1, 1039–1045.
Rossi, J., Bernini, G., Caliumi, C., Desideri, G., Fabris, B., Ferri, C., … Mantero, F. (2006). A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J. Am. Coll. Cardiol., 48, 2293–2300.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)