GENETIC DIAGNOSIS AND MECHANISMS OF CHRONIC BRONCHITIS IN CHILDREN

Authors

  • A. M. Shamsiev Samarkand State Medical Institute, Samarkand, Uzbekistan
  • Sh. A. Yusupov Samarkand State Medical Institute, Samarkand, Uzbekistan
  • L. A. Muhammadieva Samarkand State Medical Institute, Samarkand, Uzbekistan
  • B. A. Yuldashev Samarkand State Medical Institute, Samarkand, Uzbekistan

DOI:

https://doi.org/10.11603/2415-8798.2017.1.7468

Keywords:

chronic bronchitis, children, genetic risk factors, matrix metalloproteinases.

Abstract

Recent studies pay a lot of attention to genetic mechanisms of formation of chronic pulmonary diseases, especially, the role of matrix metalloproteinases (MMPs).

The aim of the study – an investigation of matrix metalloproteinases’ gene polymorphism among children with chronic bronchitis. 

Material and Methods. DNA samples of 30 children with chronic bronchitis and 100 healthy children were included into investigation.

Results and Discussion. It was found that percentage of heterozygous genotype for MMP9 (82A>G) was higher among healthy children group (46.6 and 23.3 % among patients with chronic bronchitis). Homozygous carriers of the A allele for MMP12 gene (82A4G) were prevailed among children with chronic bronchitis. Comparative study of MMP12 gene polymorphism among two groups showed increasing quantity of homozygous AA genotypes A82G of MMP12 among children with chronic bronchitis.

Conclusions. Inflammation has a crucial role in pathogenesis of chronic pulmonary diseases. The results of our investigation showed that active part of it the MMP12 are from family of matrix metalloproteinases.

Genotyping and analysis are the essential part of algorithm for physicians to find out the risk groups among children with pulmonary diseases. 

Author Biography

A. M. Shamsiev, Samarkand State Medical Institute, Samarkand, Uzbekistan

 

References

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Published

2017-04-27

How to Cite

Shamsiev, A. M., Yusupov, S. A., Muhammadieva, L. A., & Yuldashev, B. A. (2017). GENETIC DIAGNOSIS AND MECHANISMS OF CHRONIC BRONCHITIS IN CHILDREN. Bulletin of Scientific Research, (1). https://doi.org/10.11603/2415-8798.2017.1.7468

Issue

No. 1 (2017)

Section

EXCHANGE OF EXPERIENCE

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