DETERMINING THE FREQUENCY FACTORS OF CARDIOVASCULAR RISK IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Abstract

Ankylosing spondylitis is an illnes in which there is a damage to the musculoskeletal system. Mortality among patients with AS is 1.5 times higher than population levels. It is caused by cardio-vascular disease and chronic renal failure.

The aim of the study – to stratificate factors of cardiovascular risk.  

Materials and Methods. We examined 104 patients with ankylosing spondylitis (AS) using standard diagnostic methods such as the activity of the disease, lipidogram and ultrasound of intimal media of the carotid artery. Inclusion criteria in the study were: diagnosis of AS according to the modified  New York criteria and an informative patient's consent to participate in the study. Exclusion criteria in the study were: age over 60 years, the presence of psoriasis, Crohn's disease, ulcerative colitis, coronary heart disease, manifest peripheral atherosclerosis, clinically significant heart disease, circulatory insufficiency of any origin, diabetes, severe liver disease, kidney disease and other chronic diseases in their acute phases. Clinical activity of the illness was determined using the disease activity index BASDAI, BASFI functional index, an index BASMI metrology, quality of life ASQoL. To assess the 10-year risk of cardiovascular disease, the scale QRISK was used.

Results and Discussion. It was discovered that in the conditions of the higher degrees of disease activity the incidence of patients often occurs with LPL > 1.7 mg / dL, HDL-C <1.0 mmol / L, TIM thickening >0.9 mm. There was significant prolongation of the disease in this group of patients and a substantial difference in their progress in terms of VAS, CRP,  ESR, index activity and functional disorders.

Conclusions. We must assume that the problem of CVD in patient with AS is a result of systemic inflammatory disease which is associated with the development of endothelial dysfunction and increased levels of atherogenic lipids.