KINETIC OF ABSORPTION OF MIGU-6 AS A POTENTIAL PHARMACOTHERAPY OF ENDOTOXEMIA

Authors

  • V. Lukianchuk SI Institute of Pharmacology and Toxicology NAMS of Ukraine, Kyiv
  • N. Meleschenko SE Lugansk State Medical University, Rubezhnoe
  • I. Seyfullina Odessa I.I. Mechnikov National University, Odessa
  • O. Shevchuk Ternopil State Medical University, Ternopil

DOI:

https://doi.org/10.11603/2415-8798.2017.1.7100

Keywords:

coordination compounds of germanium, endotoxemia, absorption.

Abstract

An actual problem of modern medicine is a treatment of endogenous intoxication syndrome. It is polyetiological emergency condition, which requires pathogenically substantiated rational pharmacotherapy. It was proven earlier that the original coordination compound of germanium, magnesium and oxyetylidendiphosphonic acid (MIGU-6) is safe and has a high detoxifying activity at endogenous intoxication (as crush syndrome also).

The aim of the study – comparative pharmacokinetic characteristics of the absorption process of MIGU-6 in intact rats and in rats with posttraumatic endotoxemia.

Materials and Methods. Experimental model is a pathological process that occurs in rats as a result of crushing of soft tissues of lower extremities. Original compound was administered as 1% solution at a dose of 140.6 mg/kg before the crushing. The pharmacokinetic of MIGU-6 was studied by determining the concentration of germanium in tissues of animals with crush syndrome and in intact animals. Samples to study were taken in 30 minutes, 1, 4, 8, 12 and 24 hours after administration of MIGU-6.  Comparative analysis of the following parameters was performed: absorption rate constant (K01), half-absorption period (t1/2,a), maximum serum concentration (Cmax), time to reach maximum serum concentration (tmax).

Results of the studies and their discussion. Comparative analysis allows concluding that the process of absorption MIGU-6 in intact rats and in rats with posttraumatic endotoxemia goes fast enough. It was fixed higher concentrations of MIGU-6 in animals with crush syndrome, compared to healthy animals. Rate of absorption into the systemic blood flow was 0,71 h-1in healthy animals. In animals with crush syndrome it was 5.4–fold higher than those in healthy animals. Half-absorption period correlates with the absorption rate constant. Maximum serum concentration of MIGU-6 was significantly increased (152.85 μg/l) in case of endotoxemia compared to healthy rats (119.36 μg/l). tmax is 2.3-fold faster in group of animals with crush syndrome.

Conclusions. Thus, in case of posttraumatic endotoxemia, pharmacokinetic parameters of MIGU-6 absorption, undergo significant changes, such as intensification of absorption of the compounds into the systemic blood circulation.

Author Biographies

V. Lukianchuk, SI Institute of Pharmacology and Toxicology NAMS of Ukraine, Kyiv

MD, Professor, Head of the pharmacokinetics

N. Meleschenko, SE Lugansk State Medical University, Rubezhnoe

PhD, assistant professor of medicine technology, organization and economy of pharmacy pharmacology

I. Seyfullina, Odessa I.I. Mechnikov National University, Odessa

MD, Professor, Head of the Department of General chemistry and polymers street.

O. Shevchuk, Ternopil State Medical University, Ternopil

PhD, assistant professor of pharmacology clinical pharmacology

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Published

2017-04-27

How to Cite

Lukianchuk, V., Meleschenko, N., Seyfullina, I., & Shevchuk, O. (2017). KINETIC OF ABSORPTION OF MIGU-6 AS A POTENTIAL PHARMACOTHERAPY OF ENDOTOXEMIA. Bulletin of Scientific Research, (1). https://doi.org/10.11603/2415-8798.2017.1.7100

Issue

No. 1 (2017)

Section

EXPERIMENTAL RESEARCH

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