FEATURES OF EXTRA-SOMATIC DISEASES AND STRUCTURAL TRANSFORMATION OF THE ENDOMETRIUM OF WOMEN IN REPRODUCTIVE AGE WITH PRIMARY AND SECONDARY INFERTILITY
DOI:
https://doi.org/10.11603/24116-4944.2017.2.8044Keywords:
primary infertility, secondary infertility, reproductive age, соmorbidity, endometrium.Abstract
The aim of the study – to determine the characteristics of endometrium structural transformations with conditions of comorbidity of women in reproductive age with primary and secondary infertility.
Materials and Methods. Analysis of medical cases and endometrial biopsies pathomorphological research of women of reproductive age was diagnosed with infertility. Research design included gynecological, general and specialized clinical laboratory and instrumental researches. We studied an anamnesis, reproductive function, gynecological diseases, somatic status.
Results and Discussion. All women were examined in a hospital. 65.7 % of patients were diagnosed with primary infertility and 34.3 % – with secondary. Pathological changes in the endometrium, such as glandular hyperplasia, stromal polypous transformation, endometritis, registered in 55.6 % of women with primary infertility and 71.4 % in women with secondary infertility. The share of unknown causal factors did not differ significantly in both groups of subjects and was 0.4 % and 0.6 %. The abnormalities structure of functional layer of the uterus with secondary infertility was different morphologically by issues of a more pronounced glandular
structures proliferative activity in cases of glandular hyperplasia, glandular and stromal components in cases of endometrial polyps and severity of chronic inflammation, whereas in cases of primary infertility issues of endometrium proliferation activity was less expressed, except of one's evolved under thyreopaty conditions. Given the fact that as the results of our research most women with secondary infertility had extragenital pathology (81.2 % of patients) and mostly thyreopathy we should consider appropriate to further better understanding of endometrial transformation in women with infertility and their possible impact with violations of the thyroid gland.
Conclusions. The functional state of endometrium should be considered when pregnancy is planning. The structure of comorbidity in patients with secondary infertility predominant percentage of thyroid pathology. Women with thyreopathy were mostly diagnosed with primarily glandular proliferation, endometrial stromal polypous transformation, as well as two to three cases of abortions in various stages of pregnancy. The special issue of endometrial remodeling in polimorbing conditions advisable to include high frequency of glandular-cystic hyperplasia and glandular-stromal transformation.
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