PECULIARITIES OF BIOCENOSIS AND FUNCTIONAL ACTIVITY OF VAGINAL EPITHELium IN LOCAL TREATMENT OF NONSPECIFIC VAGINITIS
DOI:
https://doi.org/10.11603/24116-4944.2017.2.7865Keywords:
aerobic vaginitis, bacterial vaginosis, Clomezol, treatment, multicenter randomised controllable reserch.Abstract
The aim of the study – to evaluate the clinical and microbiological effect and safety of the drug Clomezol in the treatment of aerobic vaginitis.
Materials and Methods. To solve this problem, 60 women of reproductive age were diagnosed and treated with aerobic vaginitis. The clinical and microbiological effect of therapy in patients with aerobic vaginitis was evaluated. The time of disappearance of objective and subjective symptoms of the inflammatory process, features of the functional activity of the vaginal epithelium, the effect of the drug on the state of the normal microflora of the vagina were studied. The study was conducted in accordance with international regulations and GCP rules.
Results and Discussion. As a result of the study, it was found that the combined drug Clomezol in the form of vaginal suppositories is effective against opportunistic microorganisms – causative agents of aerobic vaginitis and is the drug of choice for the treatment of bacterial vaginosis and aerobic vaginitis. Clomezol does not perform immunosuppressive effects on the vaginal epithelium, due to this, the restoration of functional epithelium after tratment with Clomizol occurs faster than after treatment with Tergynan. Improved quality of life of patients after treatment of nonspecific vaginosis was noted.
Conclusions. High efficacy of the combined Clomezol drug against a wide spectrum of microflora was noted, high therapeutic activity and safety in use in patients with aerobic vaginitis was demonstrated. Clomezol is well tolerated and does not cause microflora resistance. The drug can be used in the II and III trimesters of pregnancy.
References
Serov, V.N. (2006). Osobennosti infektsii v akusherstve, ginekologii i perinatologii [Features of infection in obstetrics, gynecology and perinatology]. Rus. med zhurn. – Russian Medical Journal, 14(1), 2-5 [in Russian].
Кira, Е.F. (2001). Bаkterialnyy vaginoz [Bacterial vaginosis]. Nеvа Luks [in Russian].
Donders, G.G., Vereecken A., & Bosnians E. (2001). Aerobic vaginitis is an entity with abnormal vaginal flora that is distinct from bacterial vaginosis. Int. J. STD AIDS, 12(2), 68.
Donders, G.G., Vereecken, A., & Bosmans, E. (2002). Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. BJOG,109(1), 34-43.
Donders, G.G., Van Calsteren, C., & Bellen, G. (2008). Predective value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy or why metronidasole is not a good option in pregnancy. 6th European Сonference ESIDOG / Abstract Book. Plen II–2.
Downloads
Additional Files
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
