STATE OF VAGINAL BIOCENOSIS IN PREGNANTS WITH ANTENATAL DEATH OF FETUS
DOI:
https://doi.org/10.11603/24116-4944.2017.2.7800Keywords:
antental fetal death, biocenosis of vagina, infected, bacterioscopy, bacteriology.Abstract
The aim of study – to learn the microbial biocenosis of the vagina with antenatal loss of the fetus.
Materials and Methods. We examined 55 women, 30 of whom with antenatal death of fetus (АDF, principle group) and 25 women with live childbirth (control group), comparable in age, parity, somatic pathology with the main group. The study of infectious status included: microscopic examination of vaginal smears; bacteriological culture on the flora of the contents of the cervical canal; PCR diagnostics of the contents of the cervical canal, bacteriological culture of urine.
Results and Discussion. The analysis showed that among women with AFD the incidence rate (number of diseases per person) was 0.77 or 76.7 ± 4.3 %, this is 2.4 times more than in the pregnant control group (morbidity rate 0.32 or 32 ± 3.1 %, p <0.05). A frequent complication of the first half of pregnancy was early gestosis, menacing abortion, anemia (p <0.05). The level of infection in the main group was 2.6 times higher than in the control group (p <0.05). All women with vaginal infection were treated. It should be noted that during pregnancy, infection is often characterized by an asymptomatic course and frequent relapses, which may be due to changes in the hormonal balance, the presence of an immunosuppression factor associated with globulins in the serum.
Concluions. In pregnant women with AFD, the peincipal risk factors for intrauterine infection of the fetus are urogenital infections of mother, chronic foci of infection in the woman's body, their aggravation during pregnancy, infectious diseases during gestation. It is necessary to make attention to the presence of a burdened obstetric-gynecological history. Activation of opportunistic flora and prolonged exposure to an infectious agent contribute to the development of immune disorders, which in turn exacerbate the dysbiotic state, thereby supporting the inflammatory process and significantly increasing the risk of intrauterine infection of the fetus until its antenatal death.
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