CORRECTION OF LACTOSE DEFICIENCY IN INFANTS WITH SYMPTOMS OF ALLERGY TO FOODS
DOI:
https://doi.org/10.11603/24116-4944.2017.2.7796Keywords:
food allergies, gastrointestinal syndrome, lactase deficiency, drug lactase.Abstract
The aim of the study – to investigate an effort of correcting lactose deficiency to the health of infants with symptoms of allergy to foods.
Materials and Methods. The study involved 35 children aged 2 to 14 months with food allergy. The study included patients with lactase deficiency predictable for the previous definition of fecal pH values (below 5.5). Children underwent general clinical examination, scatological study the definition of fecal pH, crop fecal bacteria overgrowth dynamics.
Results and Discussion. In all the children we recorded certain manifestations of food allergy. The children were on breast feeding – 16 (45.7 %), partially breastfed – 14 (40 %) and artificial – 5 (14.3 %) feeding. In the study of microbial landscape of the intestine in most children the total number of E.coli remained in the normal range. Reducing the number of bifid bacteria and lactobacilli observed respectively in 25.7 % and 60.0 % of patients. The most observed children had pathogenic micro flora. All children after examination were prescribed the treatment that included hypoallergenic diet for breastfeeding mother and / or child, enzyme replacement therapy with lactase "Mamalak." Product – drops containing 1 ml solution in 3000 ALU lactase. The drug was administered at the rate of 750 ALU of lactase (5 drops) per 100 ml of breast milk or replacement before each
feeding period of 60 days. Every 3-rd child had clinical improvement of skin- and gastrointestinal syndromes (11–31.4%). A part of children (approx. 25 %) had positive changes in the intestinal micro flora. An amount of children rose till the end of observation up to 29 (82.9 %).
Conclusions. Infants having symptoms of allergy to food can get formed lactose deficiency. Addition of lactase medicine to
complex therapy is recommended for allergic diseases contributed to the health improvements of children in most cases.
References
Borovyk, T.E., Gribankin, S.G., & Makarova, S.G. (2011). Mekhanizmy razvitiya pishchevoy allergii [Development mechanisms of the food allergy]. Pediatriya – Paediatrics, 86, 128-134 [in Russian].
Volosovets, A.P., Kryvopustov, S.P., & Makukha, N.T. (2013). Teoreticheskoe obosnovanie preventivnoy roli kishechnoy mikrobioty v geneze allergicheskykh zabolevaniy u detey [Theoretical grounding of the preventive role of intestinal microbiome in the nature of allergic diseases in children]. Dytyachyi likar – Paediatrician, 4 (25), 5-8 [in Russian].
Okhotnikova, O.M., Hladush, Yu.I., Bondarenko, L.V., Mellina, K.V., Fedushka, G.M., & Pidvyshenna, T.V. (2015). Hastrointestinalna forma kharchovoi alerhii u ditei – aktualna problema suchasnosti [Gastrointestinal form of food allergy in children is a relevant problem of the modern age]. Zdorovye rebenka – Child’s Health, 3, 20-26 [in Ukrainian].
Revyakina, V.A. (2013). Pishchevaya allergiya, gastrointestinalnye proyavleniya [Food allergy, gastrointestinal manifestations]. Lechashchiy vrach – Consulting Physician, 4, 13-17 [in Russian].
Okhotnikova, E.N. (2013). Gastrointestinalnaya pishchevaya allergiya u detey [Gastrointestinal food allergy in children]. Klinichna imunologiya. Alergologiya. Infektologiya – Clinical Immunology. Allergology. Infectology, 2, 5-13 [in Russian].
Belitskaya, M.Yu., Sentsova, T.B., Denisova, S.N., & Kon, I.Ya. (2010). Osobennosti techeniya gastrointestinalnogo sindroma u detey pervogo goda zhizni, nahodyashchihsya na estestvennom vskarmlivanii [Characteristics of gastrointestinal syndrome in infants who are naturally feeded]. Rossiyskiy vestnik perinatologii i pediatrii – Russian Journal of Perinatal Medicine and Paediatrics, 5, 45-51 [in Russian].
Kaznacheeva, L.F. (2010). Gastrointestinalnaya forma pishchevoy allergii u detey [Gastrointestinal form of food allergy in children]. Prakticheskaya meditsina – Applied Medicine, 45, 88-92 [in Russian].
Klykova, T.V., Agafonova, E.V., & Reshetnikova, I.D. (2011). Pishchevaya allergiya u detey rannego vozrasta:podkhody k diagnostike i lecheniyu [Food allergy in infants: approaches
to diagnostic and treatment]. Prakticheskaya meditsina – Applied Medicine, 51, 125-131 [in Russian].
Abaturov, A.E., Nikylina, A.A., & Demidenko, Yu.V. (2016). Klinicheskoe znachenie izbytochnogo soderzhaniya laktozy v diete (chast 1) [The clinical relevance of excess lactose in the diet (part 1). Zdorovye rebenka – Child’s Health, 1 (69), 104-109 [in Russian].
Abaturov, A.E., Nikylina, A.A., Petrenko, L.L. (2015). Laktaznaya nedostatochnost u detey [Lactase deficiency in children]. Mezhdunarodnyy zhurnal pediatrii, akusherstva i ginekologii – International Journal of Paediatrics, Obstetrics and Gynecology, 2 (7), 51-62 [in Russian].
Shrainer, E.V., & Denisov, M.Yu. (2009). Laktaznaya nedostatochnost u detey: sovremennoe sostoyanie problem [Lactase deficiency in children: the current state of the problem]. Vestnik NGU. Seriya: Biologiya, klinicheskaya meditsina – NGU Journal. Series: Biology, Clinical Medicine, 7, 154-157 [in Russian].
Korniyenko, E.A., Minina, S.N., Fadina, S.A., Loboda, T.B. (2009). Klinika, diagnostika i lechenie lyamblioza u detey [Clinical picture, diagnostics and treatment of giardiasis in children].
Pediatricheskaya farmakologiya – Paediatric Pharmacology, 6 (4), 40-46 [in Russian].
Reshetilov, Yu.I., & Pedko, I.I., & Protsenko, N.M., & Kuznetsova, L.P., & Vasyltchenko, O.Yu., & Bohoslav, T.V. (2014). Aktualni pytannia diahnostyky ta korektsii laktaznoi nedostatnosti v ditei ta doroslykh [Relevant questions of diagnostics and management of lactase deficiency in children and adults]. Hastroenterolohiia – Gastroenterology, 4 (54), 70-75 [in Ukrainian].
Haliullina, S.V., Gutor, I.A., Amerkhanova, A.M., & Alyoskin, A.V. (2010). Vtorichnaya laktaznaya nedostatochnost v klinike rotavirusnykh kishechnykh infektsiy u detey [Secondary lactase deficiency in clinical picture of rotaviral enteric infections in children]. Prakticheskaya meditsina – Applied Medicine, 6 (45), 110-113 [in Russian].
Misnik, V.P. (2007). Neperenosimost laktozy. Sovremennye printsipy patogeneticheskoy terapii [Lactose intolerance. Modern guidelines of pathogenetic therapy]. Therapiia Ukrainskyi
medychnyi visnyk – Therapia Ukrainian Medical Journal, 12 (21) [in Russian].
Kondrakova, O.A., & Mazankova, L.M., & Zatevalov, A.M., & Begiashvili, L.V., & Babin, V.N., & Dubinin, A.V. (2008). Narusheniya mikrobiotsenoza kishechnika u detey rannego vozrasta s vtorichnoy laktaznoy nedostatochnostyu [Defects of intestinal micribiocenosis in infants with secondary lactase deficiency]. Rossiyskiy vestnik perinatologii i pediatrii – Russian Journal of Perinatal Medicine and Paediatrics, 2, 74-81 [in Russian].
Shumatova, T.A., Prikhodchenko, N.G., & Grygoryan, L.A. (2011). Patogeneticheskie i klinicheskie aspekty formirovaniya pishchevoy intolerantnosti [Pathogenetic and clinical aspects of developing of the food intolerance]. Tihookeanskiy meditsinskiy zhurnal – Pacific Medical Journal, 2, 62-65 [in Russian].
Abaturov, A.E., Nikylina, A.A., & Demidenko, Yu.V. (2016). Klinicheskoe znachenie izbytochnogo soderzhaniya laktozy v diete (chast 2) [The clinical relevance of excess lactose
in the diet (part 2). Zdorovye rebenka – Child’s Health, 2 (70), 151-157 [in Russian].
Kruglova, L.S. (2012). Simptomokompleks disbioza u bolnykh atopicheskim dermatitom i metody ego korrektsii [Set of symptoms of dysbiosis in patients with atopic dermatitis and the
methods of its management]. Lechashchiy vrach – Consulting Physician, 5, 38-44 [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).