PARVOVIRUS B19 – CLINICAL SYMPTOMATOLOGY AND COMPLICATIONS DURING PREGNANCY
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7518Keywords:
parvovirus B19, pregnancy, parvovirus infection, symptoms.Abstract
The aim of the study – to learn the features of the clinical picture and reproductive losses in pregnant women infected with parvovirus infection.
Materials and Methods. From the total survey of TORCH infection among pregnant women during 2011-2016, a core group of 58 (20.13 %) pregnant women was formed with diagnosed parvovirus infection confirmed by immunoglobulin M and immunoblot IgM and IgG to parvovirus infection B19. The control group included 40 pregnant women with uncomplicated pregnancy and deficit of M antibodies to parvovirus B19 and IgG immunoblots to parvovirus proteins VP1, NS1, VPL.
Results and Discussion. 26 (44.8 %) of pregnant women who had been diagnosed with parvovirus infection didn’t report symptoms of infectious disease during pregnancy. The remaining pregnant women noted a number of symptoms.
Clinical performance of parvovirus infection in the form of myalgia, general fatigue, subfebrile temperature, headache was observed in 12 (20.6 %) pregnant women. Erythematous rash was observed in 9 (15.5 %) infected women. 6 (10.3 %) pregnant women had symptoms of arthropathy and arthritis. 5 (8.6 %) of pregnant of women had lymphadenitis. It is noted that infected in the first and second trimesters received the greatest reproductive losses (55.1 %). Non-immune hydrops fetus occurred in 8.57 % of cases.
Conclusions. In a half of cases (44.8 %) parvovirus infection during pregnancy was asymptomatic. The analysis of reproductive loss in case of the mother infected with parvovirus B19 showed that the frozen, pregnancy, nonimmune fetal edema, antenatal fetal death are reliably associated with parvovirus B19.
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