STATE VASCULAR HOMEOSTASIS IN WOMEN WITH INFERTILITY AFTER USING ASSISTED REPRODUCTIVE TECHNOLOGIES.
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7462Keywords:
pregnancy, assisted reproductive technologies, liver, obstetric complications endothelium.Abstract
The aim of the study – to establish the role of vascular disorders of regulation in the event of perinatal complications in pregnant women at high risk.
Materials and Methods. The study involved 50 pregnant women after assisted reproductive technologies with infertility hormonal origin (study group), 50 pregnant women after assisted reproductive technology because of tubal-peritoneal factor infertility (group) and 50 somatically healthy women with non-simulate pregnancy (control group) in the period of gestation 14–16 weeks. The level of homocysteine was determined by enzyme cyclic reaction, using a set Diasyis (Germany) using the analyzer Respons 920 (Germany) of manufacturer. Content L "arginine levels determined using photometric method, which is based on the reaction of L" with hipobromidnym naphthol reagent. For the quantitative determination of human placental growth factor (PLGF) in samples of blood plasma we used immunochemical method with electrochemiluminescent detection (ECLIA).
Results and Discussion. To determine the role of violations of the regulation of vascular homeostasis in the event of pregnancy complications in the study group 2 groups were allocated: group 1 – 9 women with essential obstetric and perinatal disorders (miscarriages and died of pregnancy, preeclampsia severe, decompensated fetal distress), group 2 – 31 women without such disorders. It was established that pregnancy after assisted reproductive technology programs held from particularly severe complications in women with infertility of hormonal origin, where early pregnancy placenta formation and development took place in conditions of endothelial dysfunction, negative impact homocysteine, disorders of angiogenesis processes.
Consequently, these factors may be early prognostic markers of severe obstetric and perinatal disorders in pregnancy induced infertility in women of various origins.
Conclusions. In terms of homeostatic imbalance in this category of women abuse endothelium and vascular regulation factors underlying the pathogenesis of reproductive, obstetric and perinatal complications, which is the theoretical precondition for the development of complex pathogenesis reasonable prevention and treatment aimed at correcting violations.
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