PREVENTION AND TREATMENT OF OSTEOPENIC SYNDROME IN WOMEN WITH DEFICIENCY OF BODY WEIGHT ON THE PREGRAVID STAGE AND DURING PREGNANCY
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7437Keywords:
deficiency of body weight, pregravid stage, pregnancy, osteopenic syndrome, prevention and treatment.Abstract
The aim of the study – determination of the prevalence of osteopenic syndrome and assessing the effectiveness a combined preparation of calcium carbonate and cholecalciferol in women with deficiency of body weight on the pregravid stage and during pregnancy.
Materials and Methods. The study included 130 women with deficiency of body weight, were randomized into two groups: 65 women, are maintained by the traditionally according to protocols approved by the Ministry of Health of Ukraine, and 65 women who received supplemental combined preparation of calcium carbonate and cholecalciferol. Also, there were examined 35 women with normal body weight.
Results and Discussion. Osteopenic syndrome on the pregravid stage was observed in 32.3 % of women with deficiency of body weight, and in no one case with normal body weight (P < 0.001), at the start of pregnancy — 36.6 % versus 5.7 % (P = 0.003), and before birth — in 51.4 % versus 11.4 % (P = 0.001). In women with deficiency of body weight, on the pregravid stage there are disturbances of bone metabolism, and pregnancy on the background of decreased bone density enhances bone metabolism disorders. The analysis of the results based on the principles of evidence-based medicine indicates the effectiveness of the appointment of women with deficiency of body weight combined preparation of calcium carbonate and cholecalciferol with a pronounced osteoprotective effect whereby osteopenia frequency decreases from 51.4 % to 16.0 %, the absolute risk reduction was 35. 4 % (95 % CI 16.3–54.4 %), relative risk reduction (68.0 % (95 % CI 36.7 –84.7 %)) corresponds to a clinically significant effect.
Conclusion. We proved the high clinical efficiency of use combining of the drug with a combined preparation of calcium carbonate and cholecalciferol with a pronounced osteoprotective effect for the prevention and treatment of osteopenic syndrome in women with deficiency of body weight.
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