SIGNIFICANCE OF PREGRAVID PREPARATION OF WOMEN WITH FETAL LOSS SYNDROME ON THE BACKGROUND OF CONGENITAL FORMS OF THROMBOPHILIA
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7381Keywords:
pregravid preparation, congenital thrombophilia, fetal loss syndrome, pregnancy, gestational complications.Abstract
The aim of the study – the analysis of pregravid preparation value in women with fetal loss syndrome on the background of genetically determined forms of thrombophilia.
Materias and Methods. Retrospective and prospective analysis of the pregnancy course in 42 pregnant women with fetal loss syndrome on the background of born trombophilia was conducted. Among them 22 women underwent pregravid preparation and 20 women pregnancy in whom occurred without offered by us pregravid preparation. Control group consisted of 30 women with physiological pregnancy course. The following research methods were used: clinical, functional (echographics, cardiotocographics, dopplerometry), hemostasiological and morphological.
Results and Discussion. Thus, in women with genetically determined forms of thrombophilia, whose pregnancies had occurred without pregravid preparation, there were recorded the following complications: premature detachment of the normally located placenta in 4.76 % (2) of women, the threat of miscarriage in 9 (21.4 %) patients, the threat of premature birth in 7 (16.7 %) women, placental dysfunction in 10 (2.4 %) patients, while in women with pregravid preparation this disease was revealed less, danger of miscarriage in 5 (11.9 % ) patients, the threat of premature birth in 3 (7.1 %) women, placental dysfunction in 4 (9.5 %) patients. Ultrasound study of fetometric indicators of the fetus and antenatal assessment of placental structure allowed diagnosing the syndrome of fetal growth retardation in 11.9 % (5) of patients with thrombophilia without pregravid preparation.
Conclusions. Pregravid preparation of women with fetal loss syndrome on the background of genetically determined forms of thrombophilia is very important and helps reduce the incidence of gestational complications.
References
Ventskovskyi, B.M., Zahorodniaia, A.S. & Leush, S.St. (2015). Polimorfizm genov folatnogo obmena kak prychyna prezhdevremennykh rodov [Polymorphism of genes of folate metabolism as a reason of preterm delivery]. Reproduktivnoe zdorove – Reproductive Health, 8-15 [in Russian].
Makatsariya, A.D., Bitsadze, V.O. & Akinyshyna, S.V. (2007). Trombozy i tromboembolii v akushersko-ginekologicheskoy praktike [Thrombosis and thromboembolism in obstetric gynecological practice]. 172-216 [in Russian].
Putilova, N.V. &Bashmakova, N.V. (2012). Sovremennyie pryntsypy vedeniya patsyentok s tromboemboliyey s pozitsyi dokazatyelnoi meditsyny [Modern principles of conducting patients with thrombophilia from the perspective of evidence-based medicine]. Nauchno-praktycheskiy zhurnal «Akusherstvo i gynekologiya» – Scientific and Practical Journal of «Obstetrics and Gynecology», 6, 15-19 [in Russian].
Rybalka, A.N. & Ehorova, Ya.F. (2012). Platsentarnaya dysfunktsiya i perynatalnye potery [Placental dysfunction and perinatal loss]. Krymskiy zhurnal eksperymentalnoy i klinicheskoy medytsyny – Crimean Journal of Experimental and Clinical Medicine, 3-4 (7-8), (2), 50-54 [in Ukrainian].
Smorzhevskyi, V.Y. & Prysiazhna, N.R. (2012). Hostryi venoznyi tromboz u vahitnykh na tretiomu trymestri vahitnosti. Profilaktyka tromboembolichnykh uskladnen [Acute venous thrombosis in pregnant women in the third trimester of pregnancy. Prophylaxis of thromboembolic complications]. 117-118 [in Ukrainian].
Frolova, N.I., Byelokrynytskaya, T.Ye. & Strambovskaya, N.N. (2014). Prekontseptsyonnyi molekuliarno-geneticheskiy skrining molodykh zdorovykh zhenshchin na preduktsyiu oslozhneniy beremennosti [Preconceptional molecular-genetic screening of young healthy women on preduction of pregnncy complications]. Akusherstvo, ginekolohiya, perynatologiya, pediatriya – Obstetrics, Gynecology, Perinatology, Pediatrics, 5(4), (16), 1485-1487 [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
