VARIABILITY OF ANTIPHOSPHOLIPID ANTIBODIES CIRCULARION IN THE SECOND TRIMESTER OF PREGNANCY IN PATIENTS WITH EARLY GESTOSIS
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7363Keywords:
antiphospholipid antibodies, early gestosis.Abstract
The aim of the study – to investigate the variability of circulating antiphospholipid antibodies in pregnant women, depending on the course of the first trimester of pregnancy.
Materials and Methods. The study involved 109 pregnant women with gestational period of 11–12 weeks, who were divided into 2 groups. Group 1 included 58 pregnant women who had vomiting in the first trimester, group 2 – 51 pregnant women with uncomplicated course of the first trimester. The circulation of antibodies to phospholipids by ELISA was determined in all pregnant women in the 11–12 and 20 weeks, incidence of different subtypes of antibodies in the first and second examination depending on the course of the first trimester of pregnancy was analyzed.
Results and Discussion. The frequency of antiphospholipid antibodies circulation in the first trimester of pregnancy in both groups did not exceed 3.4–3.9 %, not more than 1–2 pregnant women in each group had a circulation of two or more subtypes of antibodies. The predominant subtype that it was found in both groups were Ig G to cardiolipin. Already in 20 weeks between the groups were found differences – in group 2 – incidence of antibodies to negatively charged phosphatidylserine reached 13.7 % and phosphatidylethanolamine neutral – 17.6 %, in the group the part of pregnant women with antibodies to phospholipids remained constant.
Conclusions. Pregnant women have variability AFA concentrations during the first half of gestation – from small detection frequency of 11–12 weeks in a significant increase in 20 weeks. Given the dominance of antiphospholipid antibodies to negatively charged phospholipids in pregnant women at 20 weeks that AFA had in the first trimester, their appearance can be a sign of early endothelial dysfunction that underlies most obstetric complications. The frequency of AFA to negatively charged phospholipids is lower among patients with vomiting in first trimester than women with uncomplicated course of the first trimester.
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