CLINICAL EFFICACY OF PENTOXIFYLLINE IN THE TREATMENT OF PREGNANT WOMEN WITH PRETERM PREMATURE RUPTURE OF MEMBRANES
DOI:
https://doi.org/10.11603/24116-4944.2017.1.7356Keywords:
premature rupture of membranes, pentoxifylline, septic complications of pregnancy and labor.Abstract
The aim of the study – to evaluate the clinical effectiveness of pentoxifylline to include comprehensive treatment of pregnant women with premature rupture of membranes.
Materials and Methods. 68 pregnant women with premature rupture of membranes at term of 24–34 weeks were examined and divided into 2 groups. 33 patients of group 1 received conventional tocolytic and antibiotic therapy, 35 pregnant women received two additional pentoxifylline. The incidence of septic complications of pregnancy, childbirth and the postpartum period were reviewed.
Results and Discussion. The additional management of pentoxifylline by premature rupture of membranes leads to a markable increasing in the proportion of patients where pregnancy was prolonged for 5 days – 31.4% against 18.2% in the conventional treatment group. With 18.2% to 2.9% the proportion of pregnant women who have encountered indications for induction of labor advance through the displays of chorioamnionitis was reduced. The frequency of hyperthermia in childbirth from 15.6% to 2.9% is decreased. Positive effect for the postpartum period courseincludes reducing of the uterus subinvolution from 30.3% to 5.7%, and long leukocytosis in the postpartum period.
Conclusions. Inclusion of pentoxifylline for comprehensive treatment of pregnant women with preterm premature rupture of membranes increases the proportion of patients with prolongation of gestation for 5 days, improving perinatal outcomes. Appointment of pentoxifylline pregnant women with premature rupture of membranes reduces the frequency of hyperthermia during labor and subinvolution of uterus in the postpartum period.
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