FEATURES OF HORMONAL HOMEOSTASIS IN EARLY WOMEN REPRODUCTIVE AGE WITH ENDOCERVICOSIS
DOI:
https://doi.org/10.11603/24116-4944.2023.1.13940Keywords:
endocervicosis, early reproductive age, hormonal homeostasisAbstract
The aim of the study – to increase the effectiveness of endocervicosis treatment in nulliparous women by improving diagnostic methods and developing an optimized algorithm of treatment and prevention measures.
Materials and Methods. The contingent of the study was 142 women of early reproductive age (20–24 years old), who did not give birth, 112 with a histologically established diagnosis of endocervicosis. Depending on the chosen method of treatment, the women were divided into two clinical groups: Group I – 55 patients with endocervicosis, who were treated according to clinical protocols (Order of the Ministry of Health of Ukraine dated 02.04.2014 No. 236 “On the approval and implementation of medical and technological documents on the standardization of medical care with dysplasia and cervical cancer”); II group – 57 women with endocervicosis, with the proposed method of treatment. The control group consisted of 30 young women who did not give birth, without pathological changes on the exocervix. In all 142 examined women, the content of gonadotropic and steroid hormones in the peripheral blood: follicle-stimulating, luteinizing, prolactin, estradiol and progesterone was studied.
Results and Discussion. The patients included in the study were aged from 18 to 25 years, the average age was 22.20±2.10. Complaints of premenstrual syndrome, algomenorrhea were noted in 14 women (12.50 %) and irregular menstruation in 23 women (20.53 %) with endocervicosis. The obtained results of the level of hormones in women of the main groups indicate the absence of probable differences on the part of three indicators: FSH, LH and estradiol. In comparison with this, the content of P was probably reduced in women with endocervicosis before treatment (p<0.05), which indicates the need to take this feature into account when carrying out treatment and prevention measures. The proposed comprehensive approach to the treatment of young women with endocervicosis who did not give birth consisted of the following. Destruction of the pathological focus was carried out by the method of argon plasma coagulation (APC) of tissues with the help of the Fotek-EA 142 device and the appointment of the hormonal contraceptive drug "Jazz-Plus" (Bayer Pharma AG, Germany) from the first day of the menstrual cycle, in which the APC was planned and further by extending the reception up to 6 months. In order to evaluate the effectiveness of the applied therapy with a monophasic oral contraceptive, attention was paid to the normalization of the menstrual cycle and the level of sex hormones 6 months after the treatment
Conclusions. Changes in hormonal status were observed in women of early reproductive age with endocervicosis and consisted of reduced levels of progesterone in women (p<0.05) compared to the control group. These changes indicate the need to take this feature into account when carrying out treatment and preventive measures.
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