CLINICAL AND LABORATORY FEATURES OF RETROSPECTIVE ANALYSIS CHARACTERISTICS EXAMINATION IN WOMEN WITH INTRAEPITHELIAL NEOPLASIA OF THE CERVIX
DOI:
https://doi.org/10.11603/24116-4944.2021.1.12421Keywords:
pathology of the cervix, papillomavirus infection, herpesvirus infection, risk factorsAbstract
The aim of the study – retrospective assessment of the history features of intraepithelial neoplasia of the cervix.
Materials and Methods. The study carried out a retrospective analysis of the case histories of 450 patients with cervical pathology (CP) compared with 30 gynecologically healthy patients.
Results and Discussion. Among the examined women, ureoplasmosis was first detected in (83.33) patients, mycoplasmosis – (30.00 %) cases, chlamydia – (43.33 %) women. Mixed infection was detected in 76.67 % of patients. The combination of these infections was found in (83.33 %) patients. Among the examined patients, herpes simplex virus (HSV) type ½ – in 16 (53.33 %), cytomegalovirus (CMV) – in 12 (40.0 %), EBV virus (Epstein-Barr) – in 3 (10.0 %) ) patients. The combination of several types of viruses was noted in (36.67 %) women. The combination of several types of viruses was noted in (76.67 %) women. When cytological examination using liquid cytology of the examined patients, LSIL was detected in (76.67 %) patients, while ASCUS – (23.33 %), and when co-testing or reflex testing, HPV of a highly oncogenic type was revealed in all patients. An analytical assessment of the significance of risk factors for the onset of CP allowed us to assume that early menarche almost triples the chances of developing CP (OR = 2.72; 95 % CI: (1.02–5.11), p <0.002), disorders of the menstrual cycle – twice (OR = 2.04; 95 % CI: (1.09–3.14), p <0.05), chronic inflammatory diseases of applications (OR = 3.14; 95 % CI: (0.91–5.14) p <0.05).
Conclusions. In patients with cervical pathology, it is advisable to conduct a comprehensive assessment of vaginal mixed infection and appropriate rehabilitation and restoration of normal microflora to prevent the development of cervical pathology. Patients with cervical pathology should be examined for the presence of viral infection and with long-term persistence of HPV and herpes viruses for more than one year should use the technique of antiviral resuscitation in general clinical practice.
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