OXIDATIVE STRESS AND ANTIOXIDANT PROTECTION IN EARLY AND LATE PREECLAMPSIA OF PREGNANT WOMEN
DOI:
https://doi.org/10.11603/24116-4944.2021.1.12362Keywords:
preeclampsia, lipids, lipid peroxidation, antioxidant protection, paraoxonase-1, pregnancy, gene polymorphismAbstract
The aim of the study – to analyze markers of oxidative stress and antioxidant protection, lipid profile indicators to determine their impact on the development of early and late preeclampsia in pregnant women.
Materials and Methods. The prospective cohort study included 20 women with early preeclampsia (EPE), 41 with late PE (LPE), and 35 with physiological pregnancy (control group (C)). The study included determination of: 192 Q → R polymorphism in paraoxonase-1 gene by polymerase chain reaction, lipid fractions, state of antioxidant system – by catalase and superoxide dismutase activity, intensity of oxidative processes – by level of TBA-active products.
Results and Discussion. Analysis of the lipid profile showed that pregnant women with early and late preeclampsia are characterized by an increase a very low density lipoproteins and atherogenic coefficient in 1.09 and 1.24 times, respectively. It was found that the activation of lipid peroxidation is typical for EPE, which is confirmed by an increase concentration of TBA-active products in 5.3 times compared with the control and in 1.54 times compared with the group with LPE (p < 0.05). Activation of lipid peroxidation processes occurs on the background of a compensatory 2-fold increase SOD activity and constant catalase activity level. It was determined that in LPE the increase of concentration of TBA-active products is less significant than in EPE, but also exceeds the C group in 3.43 times (p <0.05). In late preeclampsia, antioxidant protection did not differ significantly from the control group, which may indicate their depletion. No differences in the distribution of polymorphic variants of the PON-1192 Q → R gene between the study groups were found.
Conclusions. An increase in atherogenic fractions, an imbalance in the processes of lipid peroxidation and antioxidant protection play an important role in the development as early as late preeclampsia of pregnant women. The relationship of polymorphic variants gene 192 Q → R with the development of an imbalance in lipid peroxidation and antioxidant protection in preeclampsia has not been established.
References
Brown, M., Best, K., Pearce, M., Waugh, J., Robson, S., & Bell, R. (2013). Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis. Eur. J. Epidemiol., 28 (1), 1-19. DOI: 10.1007/s10654-013-9762-6.
Ukah, U.V., De Silva, D.A., Payne, B., Magee, L.A., Hutcheon, J.A., Brown, H., ..., & von Dadelszen, P. (2018). Prediction of adverse maternal outcomes from pre-eclampsia and other hypertensive disorders of pregnancy: a systematic review. Pregnancy Hypertens., 11, 115-123. DOI: 10.1016/j.preghy.2017.11.00.
Spradley, F.T. (2017). Metabolic abnormalities and obesity᾽s impact on the risk for developing preeclampsia. Am. J. Physiol. Regul. Integr. Comp. Physiol., 312 (1), R5-R12. DOI: 10.1152/ajpregu.00440.2016.
Iacobelli, S., Bonsante, F., & Robillard, P. (2017). Comparison of risk factors and perinatal outcomes in early onset and late onset preeclampsia: a cohort based study in Reunion Island. J. Reprod. Immunol., 123, 12-16. DOI: 10.1016/j.jri.2017.08.005.
Carty, D., Delles, C., & Dominiczak, A. (2010). Preeclampsia and future maternal health. J. Hypertens., 28 (7), 1349-1355. DOI: 10.1097/hjh.0b013e32833a39d0.
Taravati, A., & Tohidi, F. (2018). Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia. Taiwan. J. Obstet. Gynecol., 57 (6), 779-790. DOI: 10.1016/j.tjog.2018.10.002.
Loskutova, T.A. (2013). Kharakteristika obmena i perekisnogo okisleniya lipidov u beremennykh s preeklampsiyey i akusherskimi i perinatalnymi oslozhneniyami [Characteristics of lipid metabolism and peroxidation in pregnant women with preeclampsia and obstetric and perinatal complications]. Ukr. Morfol. almanakh – Ukr. Morphol. Almanac, 11 (1), 117-119 [in Russian].
Seshadri Reddy, V., Duggina, P., Vedhantam, M., Manne, M., Varma, N., & Nagaram, S. (2018). Maternal serum and fetal cord-blood ischemia-modified albumin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis. J. Matern. Fetal. Neonatal Med., 31 (24), 3255-3266. DOI: 10.1080/14767058.2017.1368480.
Cohen, J.M., Beddaoui, M., Kramer, M.S., Platt, R.W., Basso, O., & Kahn, S. R. (2015). Maternal antioxidant levels in pregnancy and risk of preeclampsia and small for gestational age birth: a systematic review and meta-analysis. PloS One, 10 (8), e0135192. DOI: 10.1371/journal.pone.0135192.
Williamson, R.D., McCarthy, C., McCarthy, F.P., & Kenny, L.C. (2017). Oxidative stress in pre-eclampsia; have we been looking in the wrong place? Pregnancy Hypertens., 8, 1-5. DOI: 10.1016/j.preghy.2017.01.004.
Draganovic, D., Lucic, N., Jojic, D., & Milicevic, S. (2017). Correlation of oxidative stress markers with ultrasound and cardiotocography parameters with hypertension induced pregnancy. Acta Inform. Med., 25 (1), 19-23. DOI: 10.5455/aim.2017.25.19-23.
Taysi, S., Tascan, A.S., Ugur, M.G., & Demir, M. (2019). Radicals, oxidative/nitrosative stress and preeclampsia. Mini Rev. Med. Chem., 19 (3), 178-193. DOI: 10.2174/1389557518666181015151350.
Poon, L., Shennan, A., Hyett, J., Kapur, A., Hadar, E., Divakar, H. …, & Hod, M. (2019). The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int. J. Gynecol. Obstet., 145 (S1), 1-33. DOI: 10.1002/ijgo.12802.
Redman, C. (2017). Early and late onset preeclampsia: Two sides of the same coin. Pregnancy Hypertens., 7, 58. DOI: 10.1016/j.preghy.2016.10.011.
Sonek, J., Krantz, D., Carmichael, J., Downing, C., Jessup, K., Haidar, Z., & McKenna, D. (2018). First-trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. Am. J. Obstet. Gynecol., 218 (1), 126.e1-126.e13. DOI: 10.1016/j.ajog.2017.10.024.
Khodzhaeva, Z.S., Kholyn, A.M., & Vykhljaeva, E.M. (2013). Rannyaya i pozdnyaya preeklampsiya: paradigmy patobiologii i klinicheskaya praktika [Early and late preeclampsia: pathobiology paradigms and clinical practice]. Akusherstvo i ginekologiya – Obstet. Gynecol., 10, 4-11 [in Russian].
Shamelashvyly K.L., Loskutova, T.A., & Shtemenko, N.Y. (2013). Korrelyatsiya pokazateley sistemy gemostaza s markerami perekisnogo okisleniya lipidov u beremennykh s preeklampsiyey [Correlation of hemostasis system indicators with markers of lipid peroxidation in pregnant women with preeclampsia]. Visnyk Kharkivskogo Natsionalnoho universytetu im. V. N. Karazina. Ser. Biolohiia – Bulletin of Kharkiv National University named after V. N. Karazin. Ser. Biology, 1056, 17, 196-202. [in Russian].
Andraweera, P., Dekker, G., Thompson, S., Dissanayake, V., Jayasekara, R., & Roberts, C. (2014). Hypoxia-inducible factor-1α gene polymorphisms in early and late onset preeclampsia in Sinhalese women. Placenta, 35 (7), 491-495. DOI: 10.1016/j.placenta.2014.04.008.
Altunina, N. (2015). Paraoksonaza-1 u khvorykh na tsukrovyi diabet 2 typu, shcho perenesly ne-Q-infarkt miokarda [Paraoxonase-1 in patients with type 2 diabetes who underwent non-Q-myocardial infarction]. Klinich. endokrynol. endokr, khirurhiia – Clin. Endocrinol. Endocr. Surg., 3 (51), 30-35 DOI: 10.24026/1818-1384.3(51).2015.75064 [in Ukrainian].
Shunmoogam, N., Naidoo, P., & Chilton, R. (2018). Paraoxonase (PON)-1: a brief overview on genetics, structure, polymorphisms and clinical relevance. Vasc. Health Risk Manag., 14, 137-143. DOI: 10.2147/VHRM.S165173.
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