MODERN VIEW ON THE ETIOLOGY, PATHOGENESIS AND POSSIBILITIES OF DIAGNOSIS OF PATHOLOGY OF THE ENDOMETRIUM AS A CAUSE OF INFERTILITY (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/24116-4944.2021.1.12360Keywords:
infertility, uterus factor, endometrial receptivity, pinopodiumAbstract
The aim of the study – a scientific review of literature on risk factors, etiology and pathogenesis of the development of endometrial pathology, methods of diagnosis the uterine factor of infertility of reproductive age women.
Materials and Methods. The work uses bibliosemantic and analytical methods. The following databases were analyzed: a scientometric database of medical and biological publications created by the National Center for Biotechnological Information (NCBI) of the US National Library of Medicine (NLM) – PUBMED and Google Academy, as a free search engine for full-text scientific publications. A significant part of gynecological diseases are directly related to the pathophysiology of the uterus, including heavy menstrual bleeding, adenomyosis, polyps, endometrial cancer, endometritis, pelvic pain, which leads to a decrease in the receptivity of the endometrium, and, as a consequence, to unsuccessful implantation, loss of pregnancy in the early stages. At the stage of IVF inception, we knew much more about the uterine factor of infertility than about the embryonic. For all these years the knowledge and technologies about in vitro fertilization stepped forward while the issues of the endometrium pathology and the entire female body as a whole, as an object of implantation, are still insufficiently covered. A lot of modern methods for overcoming the endometrial factor for infertility patients were based on empirical approaches because of our incomplete understanding of the molecular regulation of endometrial receptivity. In the past ten years, important data were published, which filled gaps in theory and postulates. As a result, it dramatically changed our understanding of the complexity of the uterus functions and the implantation as well.
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