ANTERIOR PLACENTA POSITION AS A CAUSING FACTOR OF PRE-ECLAMPSIA

Authors

  • L. I. Berlinska Odesa National Medical University
  • V. G. Marichereda Odesa National Medical University
  • O. M. Pavlovska Odesa National Medical University
  • Y. Y. Petrovskiy Odesa National Medical University

DOI:

https://doi.org/10.11603/24116-4944.2020.2.11862

Keywords:

preeclampsia, anterior location of the placenta, cystatin C, screening

Abstract

The aim of the study – to determine the frequency of preeclampsia in pregnant females with anterior location of the placenta and to determine the prognostic significance when combined with a marker of acute renal damage – cystatin C level.

Materials and Methods. In 2018–2020, a prospective cohort study that enrolled 91 pregnant women at their second trimester of gestation was conducted at Maternity Clinic and Obstetric Hospital of Maternity Hospital No. 2, Odesa. The group with the anterior location of the placenta consisted of 47 (51.65 %) pregnant women and 44 (48.35 %) had the posterior location of the placenta. Assessment of serum cystatin C was performed in women without clinical manifestations of PE at the second or third trimester of gestation (18–36 weeks), the average term was (32.22±0.41) weeks of pregnancy (p=0.011).

Results and Discussion. 28.57 % of pregnant women were subsequently diagnosed with preeclampsia (PE), of whom 19 (20.88 %) had anterior and 7 (7.69 %) posterior placenta location. Body mass index (BMI) before pregnancy, age, and height: no statistically significant difference observed between groups (p> 0.05). Analysis of maternal factors of PE in relation to the anterior location of the placenta: odds ratio (OR) higher than 1.0 was noted for combination with obesity (OR 2.38 (95 % CI 0.75–7.53)), the age over 35 years (OR 1.01 (95 % CI 0.41–2.49)) and history of PE during previous pregnancy (OR 1.38 (95 % CI 0.21–9.01)), but no statistical significance was observed (р˃0.05). When analyzing cystatin C values over 1.0 mmol/l relative to the anterior location of the placenta, the OR was 3.92 (95 % CI 1.45–10.57), sensitivity 84.09 %, specificity 42.55 %, accuracy 62.64 % were reported, p=0.011. When analyzing the frequency of preeclampsia in the anterior location of the placenta, the OR was 3.59 (95 % CI 1.32 - 9.71), sensitivity 84.09 %, specificity 40.43 %, accuracy 61.54 % were reported with statistical significance p=0.019.

Conclusions. The risk of preeclampsia in patients with the anterior location of the placenta increases by 3.59 times with a prognostic accuracy of 61.54 %. To increase the prognostic significance for the detection of preeclampsia in women with anterior location of the placenta, it is recommended to assess the serum level of cystatin C.

Author Biographies

L. I. Berlinska, Odesa National Medical University

MD, Associate Professor, Department of Obstetrics and Gynecology, Odessa National Medical University

V. G. Marichereda, Odesa National Medical University

Doctor of Medical Sciences, Professor of the Department of Obstetrics and Gynecology No. 1, Vice-Rector for Research, Odessa National Medical University

O. M. Pavlovska, Odesa National Medical University

Candidate of Medical Sciences, urologist of the consultative-diagnostic polyclinic department of the multidisciplinary medical center of Odessa National Medical University, leading specialist, Training and production complex of innovative technologies of training, informatization, continuing education and internal monitoring of the quality of education of Odessa National Medical University

Y. Y. Petrovskiy, Odesa National Medical University

Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology, Odessa National Medical University

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Published

2021-03-04

How to Cite

Berlinska, L. I., Marichereda, V. G., Pavlovska, O. M., & Petrovskiy, Y. Y. (2021). ANTERIOR PLACENTA POSITION AS A CAUSING FACTOR OF PRE-ECLAMPSIA. Actual Problems of Pediatrics, Obstetrics and Gynecology, (2), 191–196. https://doi.org/10.11603/24116-4944.2020.2.11862

Issue

No. 2 (2020)

Section

OBSTETRICS AND GYNECOLOGY

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