SOME INDICATORS OF HUMORAL IMMUNITY AND MICROBIOCENOSIS CONDITION OF REPRODUCTIVE PATHWAYS OF WOMEN-INTERNALLY DISPLACED PERSONS WITH THREATENED MISCARRIAGE
DOI:
https://doi.org/10.11603/24116-4944.2020.2.11838Keywords:
pregnancy, threatened miscarriage, microbiocenosis, laboratory diagnosticsAbstract
The aim of the study – to learn the microbiocenosis of the reproductive tract and indicators of humoral immunity of women-internally displaced persons (IDPs) with a threatened miscarriage (TM) in order to improve treatment and prophylactic measures and prevent obstetric and perinatal complications.
Materials and Methods. The study included 51 pregnant women in the first and second trimesters who were hospitalized regarding TM to the hospitals, located in Luhansk region, and who had the IDP status (group I). The control group (group II) consisted of 64 pregnant women with non-complicated obstetric anamnesis and physiological course of pregnancy with similar gestational age and place of residence. A comprehensive clinical and laboratory examination, assessment of the vaginal biocenosis by the bacterioscopic method and determination of immunoglobulins of class Ig G to Herpes simplex virus types I-II (HSV), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) were carried out.
Results and Discussion. The number of cases of nonspecific vaginitis and bacterial vaginosis was significantly more frequent (p<0.05) in women of group I (23.53 % vs 9.38 % and 19.61 % vs 6.25 %, respectively), normocenosis was significantly more frequent (p<0.05) in group II (82.81 % vs 52.94 %, respectively). Anti-Ig G HSV was detected in 90.32 % in group I and in 95.24 % in group II, anti-IgG CMV – in 80.65 % and 85.71 %, anti-IgG to the capsid antigen EBV VCA – in 74.19 % and 71.43 % of cases, respectively, antibodies to early EBV antigens (anti-IgG EBV EA) were absent in all pregnant women. The combination of anti-IgG HSV + anti-IgG CMV was noted in 70.97 % and 71.43 %, anti-IgG HSV seropositivity + anti-IgG CMV + anti-IgG EBV VCA – in 48.39 % and 52.38 % of cases respectively.
Conclusions. The prevalence of microbiocenosis disorders among pregnant women with TM in I and II trimesters and IDP status was 47.06 %. Antenatal assessment of the serological status and the state of the vaginal biocenosis at the beginning of pregnancy, regardless of clinical symptoms, will allow to individualize the approach to the management of pregnancy and, if needed, to timely develop corrective measures that will contribute to a successful outcome of the pregnancy and influence the health of the mother and her offspring
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