CONTEMPORARY VIEWS ON FEMALE INFERTILITY IN WOMEN OF ADVANCED MATERNAL AGE (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11489Keywords:
infertility, advanced maternal age, extracorporeal fertilization, folliculogenesis, induced ovulation, PRP therapyAbstract
Infertility in married couples is an issue of special importance in the contemporary medicine. The topicality of this issue in Ukraine is proved by the demographic situation, extremely aggravated in the recent years. The reasons for it are a decrease in the birth rate, an increase in the number of abortions, miscarriage and infertility. In this country, from 10 to 15 % of married couples of reproductive age are infertile, in some regions this figure is close to 20 % – a critical level that has a negative impact on demographic indicators. The pregnancy rate directly depends on the age of women and decreases by 3.3 times between the age of 19 and 48. The subtle mechanisms underlying the decreasing capacity to conceive are related to the deterioration of the quality of oocytes. The age-related increase in the frequency of atretic oocytes and degenerating embryos is probably accounted for by an increase in the number of genetic disorders in cells. Nowadays, there is a clear trend towards the planning of maternity in an advanced age. Thus, this research is aimed at analyzing the contemporary scientific publications in terms of the structure of infertility, especially in women of advanced maternal age, and the methods of medical examination as well as revising the policy of treatment to ensure a successful use of assisted reproductive technologies.
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