PROBLEMS OF CARING FOR PREMATURE BABIES AND POSSIBILITIES OF THEIR SOLUTION
DOI:
https://doi.org/10.11603/24116-4944.2020.1.11479Keywords:
premature infants, extremely premature babies, very premature babies, survival rate, morbidity, early outcomes of nursingAbstract
The aim of the study – to conduct a comparative analysis of survival rates and morbidity of premature infants (very and extremely premature infants) in perinatal centers in different countries.
Materials and Methods. Retrospective evaluation of standardized perinatal and neonatal data of premature infants with gestational age from 24+0 to 31+6 weeks, born in the perinatal center of Ternopil and Warsaw. A comparative analysis of antenatal risk factors, features of the intranatal period, anthropometric indicators at childbirth, clinical characteristics in the early neonatal period.
Results and Discussion. Comparative analysis showed that the survival rate of extremely premature infants in the Warsaw Perinatal Center is significantly higher than in the regional center (p = 0.0076). The incidence of sepsis (early, late), necrotizing enterocolitis, intraventricular hemorrhage was higher among premature infants of the Ternopil perinatal center. Most extremely premature and one-third of very premature infants in the regional center have a postnatal growth failure at discharge.
Conclusions. Comparative analysis of survival and morbidity rates among very and extremely premature babies in Ternopil and Warsaw perinatal centers revealed key differences in approaches to caring for this category of patients, to identify perinatal and neonatal risks associated with an unfavorable prognosis, to suggest possible ways to improve quality medical care.
References
Vogel, J.P., Chawanpaiboon, S., Moller, A.B., Watananirun, K., Bonet, M., & Lumbiganon, P. (2018). The global epidemiology of preterm birth. Best Pract. Res. Clin. Obstet. Gynaecol., 52, 3-12.
(2012). March of Dimes, PMNCH, Save the Children, WHO: Born Too Soon: The Global Action Report on Preterm Birth. Geneva, WHO.
Altimier, L., & Phillips, R. (2016). The neonatal integrative developmental care model: Advanced clinical applications of the seven core measures for neuroprotective family-centered developmental care. Newborn & Infant Nursing Reviews, 16, 230-244. DOI: https://doi.org/10.1053/j.nainr.2016.09.030
Lin, Y.C., Lin, Y.J., & Lin, C.H. (2011). Growth and neurodevelopmental outcomes of extremely low birth weight infants: a single center’s experience. Pediatr. Neonatol, 52, 342-348. DOI: https://doi.org/10.1016/j.pedneo.2011.08.008
Minguez-Milio, J.A., Alcázar, J.L., Aubá, M., Ruiz-Zambrana, A., & Minguez, J. (2011). Perinatal outcome and long-term follow-up of extremely low birth weight infants depending on the mode of delivery. J. Matern. Fetal Neonatal Med., 24 (10), 1235-1238. DOI: https://doi.org/10.3109/14767058.2011.552990
Lee, H.C., & Gould, J.B. (2006). Survival rates and mode of delivery for vertex preterm neonates according to small- or appropriate-for-gestational-age status. Pediatrics, 118, 1836-1844. DOI: https://doi.org/10.1542/peds.2006-1327
Godeluck, A., Gérardin, P., Lenclume, V., Mussard, C., Robillard, P.Y., Sampériz, S., …, & Ramful, D. (2019). Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies. BMC Pediatr., 19, 360. DOI: https://doi.org/10.1186/s12887-019-1700-7
Petrillo, F., Valenzano, L., Franco, C., Calò, G., Dentico, D., Manzoni, P., …, & Del Vecchio, A. (2019). Pulmonary recruitment strategy in preterm neonates < 29 weeks of gestational age to reduce the need for intubation in the delivery room. Am. J. Perinatol., 36 (02), 115-119. DOI: https://doi.org/10.1055/s-0039-1692134
Behnke, J., Lemyre, B., Czernik, C., Zimmer, K.P., Ehrhardt, H., & Waitz, M. (2019). Non-Invasive Ventilation in Neonatology. Dtsch. Arztebl. Int., 116 (11), 177-183. DOI: https://doi.org/10.3238/arztebl.2019.0177
Ramasethu, J. (2017). Prevention and treatment of neonatal nosocomial infections. Matern. Health Neonatol. Perinatol., 3, 5. DOI: https://doi.org/10.1186/s40748-017-0043-3
Polin, R.A., & Saiman, L. (2003). Nosocomial infections in the neonatal intensive care unit. NeoReviews, 4 (3), 81-89. DOI: https://doi.org/10.1542/neo.4-3-e81
Campbell-Yeo, M.L., Disher, T.C., Benoit, B.L., & Johnston, C.C. (2015). Understanding kangaroo care and its benefits to preterm infants. Pediatric Health Med. Ther., 6, 15-32. DOI: https://doi.org/10.2147/PHMT.S51869
Casper, С., Sarapuk, I., & Pavlyshyn, H. (2018). Regular and prolonged skin-to-skin contact improves short-term outcomes for very preterm infants: A dose-dependent intervention. Archives de Pédiatrie, 25 (8), 469-475. DOI: https://doi.org/10.1016/j.arcped.2018.09.008
Patel, A.L., Johnson, T.J., Engstrom, J.L., Fogg, L.F., Jegier, B.J., Bigger, H.R., & Meier, P.P. (2013). Impact of early human milk on sepsis and health care costs in very low birth weight infants. J. Perinatol, 33, 514-519. DOI: https://doi.org/10.1038/jp.2013.2
Wight, N.E. (2015). Breastfeeding the NICU infant: What to expect. Clin. Obstet. Gynecol., 58 (4), 840-854. DOI: https://doi.org/10.1097/GRF.0000000000000140
Nanou, C., Paulopoulou, I., Losis, G., Tsoumakas, K., & Saroglou, G. (2015). Risk factors for nosocomial infections in neonatal intensive care units (NICU). Health Sci. J., 9, 9.
Maffei, D., & Schanler, R.J. (2017). Human milk is the feeding strategy to prevent necrotizing enterocolitis! Semin. Perinatol., 41, 36.
Berkhouta, D.J.C., Klaassen, P., Niemarktc, H.J., de Booded, W.P., Cosseye, V., van Goudoever, G.B., …, & de Meij, T.G.J. (2018). Risk factors for necrotizing enterocolitis: A prospective multicenter case-control study. Neonatology, 114, 277-284. DOI: https://doi.org/10.1159/000489677
Ancel, P.Y., Goffinet, F., & EPIPAGE 2 Writing Group. (2014). EPIPAGE 2: a preterm birth cohort in France in 2011. BMC Pediatr., 14, 97. DOI: https://doi.org/10.1186/1471-2431-14-97
Kenet, G., Kuperman, A.A., Strauss, T., & Brenner, B. (2011). Neonatal IVH--mechanisms and management. Thromb. Res., 127, 3, S120. DOI: https://doi.org/10.1016/S0049-3848(11)70032-9
Szpecht, D., Szymankiewicz, M., Nowak, I., & Gadzinowski, J. (2016). Intraventricular hemorrhage in neonates born before 32 weeks of gestation–retrospective analysis of risk factors. Childs. Nerv. Syst., 32, 1399-1404. DOI: https://doi.org/10.1007/s00381-016-3127-x
Been, J.V., Degraeuwe, P.L., Kramer, B.W., & Zimmermann, L.J. (2011). Antenatal steroids and neonatal outcome after chorioamnionitis: a meta-analysis. BJOG, 118, 113. DOI: https://doi.org/10.1111/j.1471-0528.2010.02751.x
Mohamed, M.A., & Aly, H. (2010). Transport of premature infants is associated with increased risk for intraventricular haemorrhage. ADC Fetal Neonatal Ed., 95, F403. DOI: https://doi.org/10.1136/adc.2010.183236
Amer, R., Moddemann, D., Seshia, M., Alvaro, R.E., Lee, A.S.K., …, & Shah, P. (2018). Neurodevelopmental outcomes of infants born at <29 weeks of gestation admitted to Canadian neonatal intensive care units based on location of birth. J. Pediatr., 196, 31. DOI: https://doi.org/10.1016/j.jpeds.2017.11.038
Altaany, D., Natarajan, G., Gupta, D., Zidan, M., & Chawla. S. (2015). Severe intraventricular hemorrhage in extremely premature infants: are high carbon dioxide pressure or fluctuations the culprit? Am. J. Perinatol., 32, 839. DOI: https://doi.org/10.1055/s-0034-1543950
Ambalavanan, N., Carlo, W.A., Wrage, L.A., Das, A., Laughon, M., Cotton, C.M., …, & Higgins, R.D. (2015). PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT). ADC Fetal Neonatal Ed., 100, F145. DOI: https://doi.org/10.1136/archdischild-2014-306802
Vesoulis, Z.A., Bank, R.L., Lake, D., Wallman-Stokes, A., Sahni, R., Moorman, J.R., …, & Mathur, A.M. (2019). Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants. J. Perinatol., 39, 48. DOI: https://doi.org/10.1038/s41372-018-0236-2
Korraa, A.A., Nagger, A.A., Mohamed, R.A., & Helmy, N.M. (2014). Impact of kangaroo mother care on cerebral blood flow of preterm infants. Ital. J. Pediatr., 40, 83. DOI: https://doi.org/10.1186/s13052-014-0083-5
Davidson, L.M., & Berkelhamer, S.K. (2017). Bronchopulmonary dysplasia: chronic lung disease of infancy and long-term pulmonary outcomes. J. Clin. Med., 6 (1), pii: E4 DOI: https://doi.org/10.3390/jcm6010004
Siffel, C., Kistler, K.D., Lewis, J.F.M., & Sarda, S.P. (2019). Global incidence of bronchopulmonary dysplasia among extremely preterm infants: a systematic literature review. J. Matern. Fetal Neonatal Med., 9, 1-11. DOI: https://doi.org/10.1080/14767058.2019.1646240
Committee on Fetus and Newborn. American Academy of Pediatrics and Canadian Paediatric Society. (2002). Postnatal cotricosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics, 109 (2), 330-338.
Nelin, L.D., & Bhandari, V. (2017). How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and “tomorrow”. F1000Res., 6, 539. DOI: https://doi.org/10.12688/f1000research.10832.1
Saugstad, O.D., Aune, D., Aguar, M., Kapadia, V., Finer, N., & Vento, M. (2014). Systematic review and meta-analysis of optimal initial fraction of oxygen levels in the delivery room at ≤32 weeks. Acta Paediatr., 103 (7), 744-751. DOI: https://doi.org/10.1111/apa.12656
Oei, J.L., Vento, M., Rabi, Y., Wright, I., Finer, N., Rich, W., …, & Saugstad, O.D. (2017). Higher or lower oxygen for delivery room resuscitation of preterm infants below 28 completed weeks gestation: a metaanalysis. ADC Fetal Neonatal Ed., 102 (1), F24-F30. DOI: https://doi.org/10.1136/archdischild-2016-310435
Bubramaniam, P., Ho, J.J., & Davis, P.G. (2016). Prophylactic nasal continuous positive airway pressure for preventing morbidity and mortality in very preterm infants. Cochrane Database Syst. Rev., 6, 1465-1858.
Fenton, T.R., & Kim, J.H. (2013). A systematic review and meta-analysis to revise the fenton growth chart for preterm infants. BMC Pediatr., 13, 59. DOI: https://doi.org/10.1186/1471-2431-13-59
Li, Y.W., Yan, C.Y., Yang, L., & Han, Z.L. (2017). Effect of breastfeeding versus formula milk feeding on preterm infants in the neonatal intensive care unit. Chin. J. Contemp. Pediatr., 19 (5), 572-575.
Mihatsch, W.A., Braegger, C., Bronsky, J., Cai, W., Campoy, C., Carnielli, V., …, & Yan, W. (2018). ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition. Clin. Nutr., 37, (6 Pt B), 2303-2305. DOI: https://doi.org/10.1016/j.clnu.2018.05.029
Villar, J., Giuliani, F., Bhutta, Z., Bertino, E., Ohuma, E.O., Ismail, L.C., …, & Kennedy, S.H. (2015). Postnatal growth standards for preterm infants: the Preterm Postnatal Follow-up Study of the INTERGROWTH-21st Project. Lancet Glob. Health, 3 (11), 681-691. DOI: https://doi.org/10.1016/S2214-109X(15)00163-1
Rover, M.M., Viera, C.S., Silveira, R.C., Guimaraes, A.T., & Grassiolli, S. (2016). Risk factors associated with growth failure in the follow-up of very low birth weight newborns. J. Pediatr. (Rio J.), 92, 307-313. DOI: https://doi.org/10.1016/j.jped.2015.09.006
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