PRE-CONCEPTUAL SELECTION OF WOMEN AT HIGH RISK FOR LATE GESTOSIS (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/24116-4944.2019.2.10911Keywords:
preeclampsia, vitamin D, inhibin A, placental growth factor, endothelial dysfunctionAbstract
The aim of the study – to optimize current views on methods of diagnosis of pregnant women at high risk of late gestosis.
Preeclampsia continues to be an urgent medical and social problem as it is a widespread pathology with a high risk of complications. Despite the achievements of modern medicine, in the world structure of maternal mortality during the last ten years, preeclampsia has steadily occupied the third place after bleeding and sepsis. With regard to the pathogenesis of preeclampsia, although there are many unexplained causes, its underlying provisions are well defined. It is recognized that the central pathogenic link is generalized endothelial dysfunction. Taking into account the multifactorial influence on the processes of angiogenesis during pregnancy, the dynamics of these changes, as well as the principle of "water circle", which is manifested in PE, scientists have conducted the study of the concentration of sFlt-1 and its main antagonist – placental growth factor PlGF, as well as their relationship in pregnant women with different severity of PE and related complications. In the world of medical practice you can find many publications on the possibility of predicting the development of PE in general, as well as its severe forms. Among the latter are insulin resistance and disorders of lipid metabolism, genetic polymorphism of genes that determine the function of endothelial NO synthetase, arterio-venous index (correlation of the thoracic index of the thoracic aorta and the lower hollow perennial irregularity). The lack of effective methods of preventing PE dramatically reduces the value of all prognostic tests.
Conclusion: The lack of effective methods of prevention of PE sharply reduces the value of all prognostic tests, so it is important to study the question of modern methods of diagnosis of late gestosis in order to prevent this pathology.
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