TEMPERATURE CONTROL DURING THE THERAPEUTIC HYPOTHERMIA PERIOD IN NEONATES WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY
DOI:
https://doi.org/10.11603/24116-4944.2019.1.10177Keywords:
hypoxia, ischemia, encephalopathy, hypothermia, neonates, leukomalaciaAbstract
The aim of the study – to determine the impact of body temperature profile during therapeutic hypothermia period on outcomes of moderate to severe hypoxic-ischemic encephalopathy.
Materials and Methods. Data of 205 term infants with hypoxic-ischemic encephalopathy according to Sarnat scale stage II-III was collected during ≤72 hours of life. All the infants were stratified by the time of admission to the BAITH into the group 0–6 hours after delivery (n=56) and the group over 6 hours of life (n=149). The analysis of impact of passive hypothermia 33–35°С on outcomes of treatment of hypoxic ischemic encephalopathy was established.
Results and Discussion. There was no significant difference between study groups regarding the total duration of respiratory support (p=0.296), days of trachea extubation (p=0.468), and the length of treatment in BAITH (p=0.165). A significant difference was found in the total duration of in-hospital treatment between the group of 0–6 hours after birth and group over 6 hours of life (25 [18.3–33] days respectively, vs. 22 [14–29], p=0.032). In addition, the body temperature profile during 72 hours of hypothermia period compared between babies, which subsequently developed or did not develop cerebral leukomalacia. The results of the multivariate analysis of variance (ANOVA) did not reveal a significant difference between the groups (p=0.890).
Conclusion. Passive hypothermia with body temperature of 33–35°C is an effective procedure, the temperature fluctuation of ±0.5°C beyond the limits of this corridor, as well as the beginning of hypothermia over 6 hours after delivery, have no significant impact on the results of treatment and outcome of moderate and severe hypoxic-ischemic encephalopathy.
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