ПАТОФІЗІОЛОГІЧНІ МЕХАНІЗМИ СИНДРОМУ СТІЙКОГО ЗАПАЛЕННЯ, ІМУНОСУПРЕСІЇ І КАТАБОЛІЗМУ

(ОГЛЯД ЛІТЕРАТУРИ)

Автор(и)

  • S. M. Chuklin Львівська обласна клінічна лікарня
  • S. S. Chuklin Львівська обласна клінічна лікарня
  • G. V. Shershen Львівська обласна клінічна лікарня

DOI:

https://doi.org/10.11603/1811-2471.2020.v.i2.11300

Ключові слова:

хронічний критичний стан, запалення, імуносупресія, катаболізм

Анотація

Завдяки прогресу в галузі інтенсивної терапії рівень виживання тяжкохворих пацієнтів різко покращився. На теперішній час багатьох пацієнтів виписують з відділень інтенсивної терапії. Проте у частини таких хворих розвивається хронічний критичний стан, який характеризується постійним слабким запаленням, пригніченням імунітету і м’язовим виснаженням. У 2012 році цей стан був описаний як синдром стійкого запалення, імуносупресії і катаболізму, який може виникати після тяжкої травми і опіків, сепсису, некротичного панкреатиту.

Мета – висвітлення сучасних поглядів на механізми розвитку синдрому стійкого запалення, імуносупресії і катаболізму.

Матеріал і методи. Пошук літературних джерел проводився за базою MEDLINE.

Результати. Розмноження мієлоїдних клітин-супресорів, дисрегуляція у вродженому і адаптивному імунітеті, розвиток саркопенії є основними патофізіологічними механізмами хронічного критичного стану після тяжких запальних процесів.

Висновок. Синдром стійкого запалення, імуносупресії і катаболізму забезпечує пояснення основних патофізіологічних механізмів при хронічному критичному стані. Це є підґрунтям для визначення патогенетично спрямованого лікування, яке повинно бути багатомодальним і фокусуватися на перериванні циклу запалення/імуносупресії.

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Опубліковано

2020-08-14

Як цитувати

Chuklin, S. M., Chuklin, S. S., & Shershen, G. V. (2020). ПАТОФІЗІОЛОГІЧНІ МЕХАНІЗМИ СИНДРОМУ СТІЙКОГО ЗАПАЛЕННЯ, ІМУНОСУПРЕСІЇ І КАТАБОЛІЗМУ: (ОГЛЯД ЛІТЕРАТУРИ). Здобутки клінічної і експериментальної медицини, (2), 21–34. https://doi.org/10.11603/1811-2471.2020.v.i2.11300

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