ЛАЙМ-БОРЕЛІОЗ У ДІТЕЙ
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.11064Ключові слова:
хвороба Лайма, серологічне дослідження, нейробореліоз, лікування, дітиАнотація
В останні роки значна увага дослідників присвячена проблемам поширення захворюваності на Лайм-бореліоз і вчасної діагностики цього захворювання, зокрема у дітей. Така проблема особливо актуальна в нашій країн, оскільки за 10 років захворюваність на хворобу Лайма зросла в 27 разів.
Основна частина. На підставі ретельного і глибокого аналізу літератури в статті розглядаються проблеми діагностування хвороби Лайма, спричиненої збудниками, які потрапляють в організм унаслідок укусу інфікованих кліщів. У дітей і дорослих тривалий анамнез цих захворювань призводить до тяжких, часом незворотних наслідків. Вони можуть бути пов’язані з неадекватним і несвоєчасним встановленням діагнозу, що є серйозною проблемою, над вирішенням якої працюють учені багатьох країн світу.
Висновок. Хвороба Лайма – це ендемічне захворювання, що набуває характеру пандемії, тому що число хворих на Лайм-бореліоз зростає. Імунітет проти Borrelia burgdorferi не довічний, і у частини людей, що перенесли Лайм-бореліоз (ЛБ), через деякий час можливе повторне зараження. Емпіричне лікування може знизити імунну відповідь, що призведе до помилково негативних результатів серологічних тестів.
Посилання
Stanek, G., Wormser, G.P., Gray, J., & Strle, F. (2012). Lyme borreliosis. Lancet, 379, 461-473. DOI: https://doi.org/10.1016/S0140-6736(11)60103-7
Balmelli, T., & Piffaretti, J.C. (1995). Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Research in Microbiology, 146, 4, 329-340. DOI: https://doi.org/10.1016/0923-2508(96)81056-4
Esposito, S., Bosis, S., Sabatini, C., Tagliaferri, L., & Principi, N. (2013). Borrelia burgdorferi Infection and Lyme disease in children. International Journal of Infectious Diseases, 17, 3, 153-158.
Fingerle, V., Schulte-Spechtel, U.C., Ruzic-Sabljic, E., Leonhard, S., Hofmann, H., Weber, K., ..., & Wilske, B. (2008). Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov. International Journal of Medical Microbiology, 298, 3-4, 279-290.
Stanek, G., & Reiter, M. (2011). The expanding Lyme Borrelia complex –clinical significance of genomic species? Institute for Hygiene and Applied Immunology, Medical University of Vienna. Vienna, Austria. Retrieved from: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1469-0691.2011.03492.x
Strle, F., & Stanek, G. (2009). Clinical manifestations and diagnosis of lyme borreliosis. Current Problems in Dermatology, 37, 51-110. DOI: https://doi.org/10.1159/000213070
Steer, A.C. (2010). Lyme borreliosis. Harrison’s Infectious Diseases. D.L. Casper & A.S. Fauci eds. 17th ed. The McGraw-Hill Companies, Inc.: New York.
Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., ..., & Norrby, R. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333, 20, 1319-1327.
Dryden, M.S., Saeed, K., Ogborn, S., & Swales, P. (2015). Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiology and Infection, 143, 3, 561-572.
Karan, L., Makenov, M., Kolyasnikova, N., Stukolova, O., Toporkova, M., & Olenkova, O. (2018). Dynamics of Spirochetemia and Early PCR Detection of Borrelia miyamotoi. Emerg. Infect. Dis., 24 (5), 860-867. DOI: 10.3201/eid2405.170829. DOI: https://doi.org/10.3201/eid2405.170829
Steere, A.C. (2001). Lyme disease. N. Engl. J. Med., 345 (2), 115-125. DOI: 10.1056/nejm200107123450207 DOI: https://doi.org/10.1056/NEJM200107123450207
Lewandrowski, K., & Prisco, L. (2015). The Challenges of Lyme Disease: From Clinical Diagnosis to Testing Methodology. Advance Healthcare Network for Laboratory. King of Prussia, PA.
Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., ..., & Norrby, R. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333, 20, 1319-1327.
Centers for Disease Control and Prevention. (2012). Reported Cases of Lyme Disease by Year, United States, 2002-2011. Retrieved from: http://www.cdc.gov/lyme/stats/chartstables/casesbyyear.html
Dryden, M.S., Saeed, K., Ogborn, S., & Swales, P. (2015). Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiology and Infection, 143, 3, 561-572. DOI: https://doi.org/10.1017/S0950268814001071
Philip, S.S. (2013). Current Medical Diagnosis and Treatment. Spirochetal Infections. New York: McGraw-Hill. Retrieved from : http://www.accessmedicine.com.eres.library.manoa.hawaii.edu/content.aspx?aID=18802&searchStr=lyme+disease
Caulfield, A.J., & Pritt, B.S. (2015). Lyme disease coinfections in the United States. Clin. Lab. Med., 35, 4, 827-846. DOI: https://doi.org/10.1016/j.cll.2015.07.006
Wilking, H., & Stark, K. (2014). Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany. Ticks and Tick-borne Diseases, 5, 3, 219-224. DOI: https://doi.org/10.1016/j.ttbdis.2013.10.010
Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., ..., & Norrby, R. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333, 20, 1319-1327. DOI: https://doi.org/10.1056/NEJM199511163332004
Nau, R., Christen, H.J., & Eiffert, H. (2009). Lyme disease: current state of knowledge. Dtsch. Arztebl. Int., 106, 72-81. DOI: https://doi.org/10.3238/arztebl.2009.0525
Lobzin, Yu.V., Rakhmanova, A.G., & Antonov, V.S. (2000). Rekomendatsii dlya vrachey [Recommendations for doctors]. Saint-Petersburg [in Russian].
Penyevskaya, N.A., Rudakov, N.V., Abramova, N.V., Rudakova, S.A., & Kolomenskiy A.P. (2009). Kliniko-epidemiologicheskiy analiz rezultatov vyyavleniya antitel k razlichnym vidam rikketsiy u bolnykh s podozreniyem na kleshchevuyu neyroinfektsiyu v severnykh rayonakh Omskoy oblasti [Clinical and epidemiological analysis of the results of the detection of antibodies to various types of rickettsia in patients with suspected tick-borne neuroinfection in the northern regions of the Omsk region]. Sibirskiy meditsinskiy zhurnal – Siberian Medical Journal, 8, 48-53 [in Russian].
Drakina, S.A., Anisko, L.A., Shcherba, V.V., Samoylova, T.I., & Krasko, A.G. (2018). Mikst-infektsiya: kleshchevoy entsefalit i granulotsitarniy anaplazmoz cheloveka [Mixed infection: tick-borne encephalitis and human granulocytic anaplasmosis]. Klinicheskaya infektologiya i parazitologiya – Clinical Infectology and Parasitology, 1, 21-26 [in Russian].
Halperin, J.J. (2010). Nervous system Lyme disease. J. R. Coll. Physicians Edinb., 40, 248-255. DOI: https://doi.org/10.4997/JRCPE.2010.314
Henningsson, A.J., Christiansson, M., Tjernberg, I., & Löfgren, S., & Matussek, A. (2014). Laboratory diagnosis of Lyme neuroborreliosis: a comparison of three CSF anti-Borrelia antibody assays. Eur. J. Clin. Microbial Infect., 33, 797-803. DOI: https://doi.org/10.1007/s10096-013-2014-6
Volokha, A.P. (2016). Khvoroba Laima (klishchovyi borelioz). Infektsiini khvoroby u ditei [Lyme disease (tick borreliosis). Infectious diseases in children]. Chernyshova, L.I. (Ed). Kyiv: VSV “Medytsyna” [in Ukrainian].
(2018). Lyme disease: summary of NICE guidance. BMJ, 361, k1261. DOI: https://doi.org/10.1136/bmj.k1261. DOI: https://doi.org/10.1136/bmj.k1261
Mygland, A., Ljøstad, U., Fingerle, V., Rupprecht, T., Schmutzhard, E., & Steiner, I. (2010). EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur. J. Neurology, 17, 8-16. DOI: https://doi.org/10.1111/j.1468-1331.2009.02862.x
Karavayev, V.S., Oleynikova, Ye.S., Azayev, M.Sh., & Beklemishev, A.B. (2016). Immunokhimicheskiy analiz rekombinantnogo khimernogo polipeptida OspC [gar+afz] izolyatov borrelia garini i b. afzelli [Immunochemical analysis of recombinant chimeric polypeptide OspC [gar+afz] isolates borrelia garini and b. afzelli]. Zhurnal mikrobiologii, epidemiologii i immunobiologii – Journal of Microbiology, Epidemiology and Immunobiology, 3, 37-44 [in Russian].
Dressler, F., Ackermann, R., & Steere, A.C. (1994). Antibody responses to the three genomic groups of Borrelia burgdorferi in European Lyme borreliosis. J. Infect. Dis., 169 (2), 313-318. DOI: https://doi.org/10.1093/infdis/169.2.313
Norman, G.L., Antig, J.M., Bigaignon, G., & Hogrefe, W.R. (1996). Serodiagnosis of Lyme borreliosis by Borrelia burgdorferi sensu stricto, B. garinii, and B. afzelii western blots (immunoblots). J. Clin. Microbiol., 34 (7), 1732-1738.
Euroimmun, A.G., Komorowski, L., Probst, C., & Janssen, A. (2010). Dimerisation of recombinan osp C leads to an antigen with enhanced potential for active vaccination. Proceedings from: 12. International Conference on Lyme Borreliosis and other Tick-Bome Diseases. Slovenien: Liubliana.
Esposito, S., Bosis, S., Sabatini, C., Tagliaferri, L., & Principi, N. (2013). Borrelia burgdorferi infection and Lyme disease in children. International Journal of Infectious Diseases, 17, 3, e153-e158. DOI: https://doi.org/10.1016/j.ijid.2012.09.014
Nykytyuk, S.O., Kostyk, M.M., Kizan, S.V., & Borys, Z. Ya. (2018). Vypadok hostroho neiroboreliozu u khlopchyka shkilnoho viku [The case of acute neuroboreliosis in a boy of school age]. Aktualna Infektolohiia – Current Infectology, 6, 4, 53-54 [in Ukrainian].
Klymniuk, S.I., Romaniuk, L.B., & Shkilna, M.I. (2017). Suchasni uiavlennia pro hranulotsytarnyi anaplazmoz liudyny [Modern views about the granulocytic anaplasmosis of a man]. Infektsiini khvoroby – Infectious Diseases, 3, 4-9 [in Ukrainian].
Steere, A.C., McHugh, G., Suarez, C., Hoitt, J., Damle, N., & Sikand, V.K. (2003). Prospective study of coinfection in patients with erythema migrans. Clin. Infect. Dis., 36, 1078-1081. DOI: https://doi.org/10.1086/368187
Södermark, L., Sigurdsson, V., Näs, W., Wall, P., & Trollfors, B. (2017). Neuroborreliosis in Swedish Children: A Population-based Study on Incidence and Clinical Characteristics. Pediatr. Infect. Dis. J., 36 (11), 1052-1056. DOI: 10.1097/INF.0000000000001653. DOI: https://doi.org/10.1097/INF.0000000000001653
Dahl, V., Wisell, K.T., Giske, C.G., Tegnell, A., Wallensten, A. (2019). Lyme neuroborreliosis epidemiology in Sweden 2010 to 2014: clinical microbiology laboratories are a better data source than the hospital discharge diagnosis register separator commenting unavailable. Euro Surveill., 24 (20). DOI: 10.2807/1560-7917.ES.2019.24.20.1800453. DOI: https://doi.org/10.2807/1560-7917.ES.2019.24.20.1800453
Shkilna, M.I. (2016). Laym-borelioz u pratsivnykiv lisovykh hospodarstv Ternopilskoi oblasti [Lyme-borreliosis in forestry workers in Ternopil region]. Infektsiini khvoroby – Infectious Diseases, 1 (83), 36-40 [in Ukrainian].
Weber, K. (2001). Aspects of Lyme borreliosis in Europe. European Journal of Clinical Microbiology & Infectious Diseases, 20, 1, 6-13. DOI: https://doi.org/10.1007/s100960000412
Tsentralizovannaya informatsionnaya sistema po infektsionnym zabolevaniyam Yevropeyskogo regionarnogo byuro VOZ. (2019). Retrieved from: http://www.euro.who.int/en/search?q=lyme+disease+in+ukraine.
Bartosik, K., Kubrak, T., Olszewski, T., Jung, M., & Buczek, A. (2008). Prevention of tick bites and protection against tick-borne diseases in south-eastern Poland. Annals of Agricultural and Environmental Medicine, 15, 2, 181-185.
Murina, Е.А., Goleva, O.V., Osipova, Z.A., & Mukomolova, A.L. (2018). Problemy serologicheskoy diagnostiki iksodovogo kleshchevogo borrelioza u detey [The problems of serologicl diagnostics of tick-borne borreliosis in children]. Laboratoriya LPU. Spetsvypusk – Laboratory LPU. Special Issue, 13. Retrieved from: http://www.poliklin.ru/imagearticle/20184(1)/38.pdf
Test Suspected Lyme Borreliosis In Children. 10th WFPICCS CONGRESS. Family practice News. October.15.2005.
Wang, G., Iyer, R., Bittker, S., Cooper, D., Small, J., Wormser, G.P., & Schwartz, I. (2004). Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates. Infect. Immun., 72 (11), 6702-6706. DOI: 10.1128/IAI.72.11.6702-6706.2004. DOI: https://doi.org/10.1128/IAI.72.11.6702-6706.2004
Centers for Disease Control and Prevention. Lyme disease (Borrelia burgdorferi): 2017 case definition. Retrieved from: https://wwwn.cdc.gov/nndss/conditions/ lyme-disease/case-definition/2017.
Retrieved from: https://guidelines.moz.gov.ua/documents/2959.
Retrieved from: https://ru.wikipedia.org/wiki/%D0%91%D0%BE%D0%BB%D0%B5%D0%B7%D0%BD%D1%8C_%D0%9B%D0%B0%D0%B9%D0%BC%D0%B0.
Nyman, D., & Wahlberg, P. (2017). Lyme borreliosis (LB). EBM Guidelines. Retrieved from: https://www.ebm-guidelines.com/dtk/ebmaz/avaa?p_artikkeli=ebm00031
Stanek, G., Fingerle, V., Hunfeld, K.P., Jaulhac, B., Kaiser, R., Krause, A., ..., & Gray, J. (2011). Lyme borreliosis: Clinical case definitions for diagnosis and management in Europe. Clin. Microbiol. Infect., 17 (1), 69-79. DOI: https://doi.org/10.1111/j.1469-0691.2010.03175.x
Smiyan, S., Galaychuk, I., Zhulkevych, I., Nykolyuk, V., Komorovsky, R., Gusak, S., Bilozetsky, I. (2019). Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme diseas. Reumatologia, 57 (1), 59-62. Retrieved from: https://doi.org/10.5114/reum.2019.83242 DOI: https://doi.org/10.5114/reum.2019.83242
Galaychuk, I.Y., Zhulkevych, I.V., Smiyan, S.I., Nykolyuk, V.D., & Komorovsky, R.R. (2019). Boreliozna limfadenopatiia u praktytsi onkoloha (klinichni sposterezhennia). [Borrelious lymphadenopathy in oncology practice (clinical observations)]. Onkolohiia – Oncology, 21, 3. DOI: 10.32471/oncology.2663-7928.t-21-3-2019-g.7896. Retrieved from: URL: https://www.oncology.kiev.ua/article/7896/boreliozna-limfadenopatiya-u-praktici-onkologa-klinichni-sposterezhennya [in Ukrainian].
Lazynska, A.S., Kostyarkova, M.M., & Ivanova, S.M. (Eds.). (2010). Medical Microbiology Guide. Private medical Microbiology and etiologic diagnosis of infections. Book II/Col. The publishing house BYNOM.
Kopcha, V.S., Vasylieva, N.I., & Shkilna, M.I. (2016). Diahnostychni mozhlyvosti imunnoho blotynhu pry boreliozi [Diagnostic and immune blotting in case of borelioz]. Retrieved from: https://health-ua.com/article/6780-dagnostichn-mozhlivost-munnogo-blotingu-pri-boreloz.
Nykytyuk, S., Podobivsky, S.S., Klymnyuk, S.I., & Fedoniuk, L.Y. European Journal of Pediatrics, 178 (11), 1714-1714.
Nykytyuk, S., Klymnyuk, S., & Levenets, S. (2019). Laboratory diagnostics of lyme borreliosis in children with ticks bites in ternopil region. Georgian Medical News, 11 (296), 32-36.
