LYME BORRELIOSIS IN CHILDREN
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i1.11064Keywords:
Lyme disease, serological examination, borreliosisAbstract
In recent years, considerable attention has been paid to the problems of the spread of Lyme borreliosis and the timely diagnosis of this disease, particularly in children. The problem in our country is especially urgent, as in 10 years the incidence of Lyme disease is increased in 27 times.
The main body. On the basis of a thorough analysis of the literature, the article deals with the problems of diagnosing Lyme disease, neurobereliosis and other diseases caused by pathogens that enter the body due to the bite of infected ticks. In children and adults a long history of these diseases leads to severe, sometimes irreversible consequences. These consequences may be related to inadequate and untimely diagnosis, which is a serious problem that is being addressed by scientists in many countries around the world.
Conclusion. Lyme disease is an endemic disease that is becoming a pandemic, and the number of children with Lyme borreliosis is increasing. Immunity against Borrelia burgdorferi is not life-long, and some people who have had LB may have re-infection after some time. Empirical treatment can reduce the immune response, leading to erroneously negative results of serological tests.
References
Stanek, G., Wormser, G.P., Gray, J., & Strle, F. (2012). Lyme borreliosis. Lancet, 379, 461-473. DOI: https://doi.org/10.1016/S0140-6736(11)60103-7
Balmelli, T., & Piffaretti, J.C. (1995). Association between different clinical manifestations of Lyme disease and different species of Borrelia burgdorferi sensu lato. Research in Microbiology, 146, 4, 329-340. DOI: https://doi.org/10.1016/0923-2508(96)81056-4
Esposito, S., Bosis, S., Sabatini, C., Tagliaferri, L., & Principi, N. (2013). Borrelia burgdorferi Infection and Lyme disease in children. International Journal of Infectious Diseases, 17, 3, 153-158.
Fingerle, V., Schulte-Spechtel, U.C., Ruzic-Sabljic, E., Leonhard, S., Hofmann, H., Weber, K., ..., & Wilske, B. (2008). Epidemiological aspects and molecular characterization of Borrelia burgdorferi s.l. from southern Germany with special respect to the new species Borrelia spielmanii sp. nov. International Journal of Medical Microbiology, 298, 3-4, 279-290.
Stanek, G., & Reiter, M. (2011). The expanding Lyme Borrelia complex –clinical significance of genomic species? Institute for Hygiene and Applied Immunology, Medical University of Vienna. Vienna, Austria. Retrieved from: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1469-0691.2011.03492.x
Strle, F., & Stanek, G. (2009). Clinical manifestations and diagnosis of lyme borreliosis. Current Problems in Dermatology, 37, 51-110. DOI: https://doi.org/10.1159/000213070
Steer, A.C. (2010). Lyme borreliosis. Harrison’s Infectious Diseases. D.L. Casper & A.S. Fauci eds. 17th ed. The McGraw-Hill Companies, Inc.: New York.
Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., ..., & Norrby, R. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333, 20, 1319-1327.
Dryden, M.S., Saeed, K., Ogborn, S., & Swales, P. (2015). Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiology and Infection, 143, 3, 561-572.
Karan, L., Makenov, M., Kolyasnikova, N., Stukolova, O., Toporkova, M., & Olenkova, O. (2018). Dynamics of Spirochetemia and Early PCR Detection of Borrelia miyamotoi. Emerg. Infect. Dis., 24 (5), 860-867. DOI: 10.3201/eid2405.170829. DOI: https://doi.org/10.3201/eid2405.170829
Steere, A.C. (2001). Lyme disease. N. Engl. J. Med., 345 (2), 115-125. DOI: 10.1056/nejm200107123450207 DOI: https://doi.org/10.1056/NEJM200107123450207
Lewandrowski, K., & Prisco, L. (2015). The Challenges of Lyme Disease: From Clinical Diagnosis to Testing Methodology. Advance Healthcare Network for Laboratory. King of Prussia, PA.
Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., ..., & Norrby, R. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333, 20, 1319-1327.
Centers for Disease Control and Prevention. (2012). Reported Cases of Lyme Disease by Year, United States, 2002-2011. Retrieved from: http://www.cdc.gov/lyme/stats/chartstables/casesbyyear.html
Dryden, M.S., Saeed, K., Ogborn, S., & Swales, P. (2015). Lyme borreliosis in southern United Kingdom and a case for a new syndrome, chronic arthropod-borne neuropathy. Epidemiology and Infection, 143, 3, 561-572. DOI: https://doi.org/10.1017/S0950268814001071
Philip, S.S. (2013). Current Medical Diagnosis and Treatment. Spirochetal Infections. New York: McGraw-Hill. Retrieved from : http://www.accessmedicine.com.eres.library.manoa.hawaii.edu/content.aspx?aID=18802&searchStr=lyme+disease
Caulfield, A.J., & Pritt, B.S. (2015). Lyme disease coinfections in the United States. Clin. Lab. Med., 35, 4, 827-846. DOI: https://doi.org/10.1016/j.cll.2015.07.006
Wilking, H., & Stark, K. (2014). Trends in surveillance data of human Lyme borreliosis from six federal states in eastern Germany. Ticks and Tick-borne Diseases, 5, 3, 219-224. DOI: https://doi.org/10.1016/j.ttbdis.2013.10.010
Berglund, J., Eitrem, R., Ornstein, K., Lindberg, A., Ringer, A., Elmrud, H., ..., & Norrby, R. (1995). An epidemiologic study of Lyme disease in southern Sweden. English Medical Journal, 333, 20, 1319-1327. DOI: https://doi.org/10.1056/NEJM199511163332004
Nau, R., Christen, H.J., & Eiffert, H. (2009). Lyme disease: current state of knowledge. Dtsch. Arztebl. Int., 106, 72-81. DOI: https://doi.org/10.3238/arztebl.2009.0525
Lobzin, Yu.V., Rakhmanova, A.G., & Antonov, V.S. (2000). Rekomendatsii dlya vrachey [Recommendations for doctors]. Saint-Petersburg [in Russian].
Penyevskaya, N.A., Rudakov, N.V., Abramova, N.V., Rudakova, S.A., & Kolomenskiy A.P. (2009). Kliniko-epidemiologicheskiy analiz rezultatov vyyavleniya antitel k razlichnym vidam rikketsiy u bolnykh s podozreniyem na kleshchevuyu neyroinfektsiyu v severnykh rayonakh Omskoy oblasti [Clinical and epidemiological analysis of the results of the detection of antibodies to various types of rickettsia in patients with suspected tick-borne neuroinfection in the northern regions of the Omsk region]. Sibirskiy meditsinskiy zhurnal – Siberian Medical Journal, 8, 48-53 [in Russian].
Drakina, S.A., Anisko, L.A., Shcherba, V.V., Samoylova, T.I., & Krasko, A.G. (2018). Mikst-infektsiya: kleshchevoy entsefalit i granulotsitarniy anaplazmoz cheloveka [Mixed infection: tick-borne encephalitis and human granulocytic anaplasmosis]. Klinicheskaya infektologiya i parazitologiya – Clinical Infectology and Parasitology, 1, 21-26 [in Russian].
Halperin, J.J. (2010). Nervous system Lyme disease. J. R. Coll. Physicians Edinb., 40, 248-255. DOI: https://doi.org/10.4997/JRCPE.2010.314
Henningsson, A.J., Christiansson, M., Tjernberg, I., & Löfgren, S., & Matussek, A. (2014). Laboratory diagnosis of Lyme neuroborreliosis: a comparison of three CSF anti-Borrelia antibody assays. Eur. J. Clin. Microbial Infect., 33, 797-803. DOI: https://doi.org/10.1007/s10096-013-2014-6
Volokha, A.P. (2016). Khvoroba Laima (klishchovyi borelioz). Infektsiini khvoroby u ditei [Lyme disease (tick borreliosis). Infectious diseases in children]. Chernyshova, L.I. (Ed). Kyiv: VSV “Medytsyna” [in Ukrainian].
(2018). Lyme disease: summary of NICE guidance. BMJ, 361, k1261. DOI: https://doi.org/10.1136/bmj.k1261. DOI: https://doi.org/10.1136/bmj.k1261
Mygland, A., Ljøstad, U., Fingerle, V., Rupprecht, T., Schmutzhard, E., & Steiner, I. (2010). EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur. J. Neurology, 17, 8-16. DOI: https://doi.org/10.1111/j.1468-1331.2009.02862.x
Karavayev, V.S., Oleynikova, Ye.S., Azayev, M.Sh., & Beklemishev, A.B. (2016). Immunokhimicheskiy analiz rekombinantnogo khimernogo polipeptida OspC [gar+afz] izolyatov borrelia garini i b. afzelli [Immunochemical analysis of recombinant chimeric polypeptide OspC [gar+afz] isolates borrelia garini and b. afzelli]. Zhurnal mikrobiologii, epidemiologii i immunobiologii – Journal of Microbiology, Epidemiology and Immunobiology, 3, 37-44 [in Russian].
Dressler, F., Ackermann, R., & Steere, A.C. (1994). Antibody responses to the three genomic groups of Borrelia burgdorferi in European Lyme borreliosis. J. Infect. Dis., 169 (2), 313-318. DOI: https://doi.org/10.1093/infdis/169.2.313
Norman, G.L., Antig, J.M., Bigaignon, G., & Hogrefe, W.R. (1996). Serodiagnosis of Lyme borreliosis by Borrelia burgdorferi sensu stricto, B. garinii, and B. afzelii western blots (immunoblots). J. Clin. Microbiol., 34 (7), 1732-1738.
Euroimmun, A.G., Komorowski, L., Probst, C., & Janssen, A. (2010). Dimerisation of recombinan osp C leads to an antigen with enhanced potential for active vaccination. Proceedings from: 12. International Conference on Lyme Borreliosis and other Tick-Bome Diseases. Slovenien: Liubliana.
Esposito, S., Bosis, S., Sabatini, C., Tagliaferri, L., & Principi, N. (2013). Borrelia burgdorferi infection and Lyme disease in children. International Journal of Infectious Diseases, 17, 3, e153-e158. DOI: https://doi.org/10.1016/j.ijid.2012.09.014
Nykytyuk, S.O., Kostyk, M.M., Kizan, S.V., & Borys, Z. Ya. (2018). Vypadok hostroho neiroboreliozu u khlopchyka shkilnoho viku [The case of acute neuroboreliosis in a boy of school age]. Aktualna Infektolohiia – Current Infectology, 6, 4, 53-54 [in Ukrainian].
Klymniuk, S.I., Romaniuk, L.B., & Shkilna, M.I. (2017). Suchasni uiavlennia pro hranulotsytarnyi anaplazmoz liudyny [Modern views about the granulocytic anaplasmosis of a man]. Infektsiini khvoroby – Infectious Diseases, 3, 4-9 [in Ukrainian].
Steere, A.C., McHugh, G., Suarez, C., Hoitt, J., Damle, N., & Sikand, V.K. (2003). Prospective study of coinfection in patients with erythema migrans. Clin. Infect. Dis., 36, 1078-1081. DOI: https://doi.org/10.1086/368187
Södermark, L., Sigurdsson, V., Näs, W., Wall, P., & Trollfors, B. (2017). Neuroborreliosis in Swedish Children: A Population-based Study on Incidence and Clinical Characteristics. Pediatr. Infect. Dis. J., 36 (11), 1052-1056. DOI: 10.1097/INF.0000000000001653. DOI: https://doi.org/10.1097/INF.0000000000001653
Dahl, V., Wisell, K.T., Giske, C.G., Tegnell, A., Wallensten, A. (2019). Lyme neuroborreliosis epidemiology in Sweden 2010 to 2014: clinical microbiology laboratories are a better data source than the hospital discharge diagnosis register separator commenting unavailable. Euro Surveill., 24 (20). DOI: 10.2807/1560-7917.ES.2019.24.20.1800453. DOI: https://doi.org/10.2807/1560-7917.ES.2019.24.20.1800453
Shkilna, M.I. (2016). Laym-borelioz u pratsivnykiv lisovykh hospodarstv Ternopilskoi oblasti [Lyme-borreliosis in forestry workers in Ternopil region]. Infektsiini khvoroby – Infectious Diseases, 1 (83), 36-40 [in Ukrainian].
Weber, K. (2001). Aspects of Lyme borreliosis in Europe. European Journal of Clinical Microbiology & Infectious Diseases, 20, 1, 6-13. DOI: https://doi.org/10.1007/s100960000412
Tsentralizovannaya informatsionnaya sistema po infektsionnym zabolevaniyam Yevropeyskogo regionarnogo byuro VOZ. (2019). Retrieved from: http://www.euro.who.int/en/search?q=lyme+disease+in+ukraine.
Bartosik, K., Kubrak, T., Olszewski, T., Jung, M., & Buczek, A. (2008). Prevention of tick bites and protection against tick-borne diseases in south-eastern Poland. Annals of Agricultural and Environmental Medicine, 15, 2, 181-185.
Murina, Е.А., Goleva, O.V., Osipova, Z.A., & Mukomolova, A.L. (2018). Problemy serologicheskoy diagnostiki iksodovogo kleshchevogo borrelioza u detey [The problems of serologicl diagnostics of tick-borne borreliosis in children]. Laboratoriya LPU. Spetsvypusk – Laboratory LPU. Special Issue, 13. Retrieved from: http://www.poliklin.ru/imagearticle/20184(1)/38.pdf
Test Suspected Lyme Borreliosis In Children. 10th WFPICCS CONGRESS. Family practice News. October.15.2005.
Wang, G., Iyer, R., Bittker, S., Cooper, D., Small, J., Wormser, G.P., & Schwartz, I. (2004). Variations in Barbour-Stoenner-Kelly culture medium modulate infectivity and pathogenicity of Borrelia burgdorferi clinical isolates. Infect. Immun., 72 (11), 6702-6706. DOI: 10.1128/IAI.72.11.6702-6706.2004. DOI: https://doi.org/10.1128/IAI.72.11.6702-6706.2004
Centers for Disease Control and Prevention. Lyme disease (Borrelia burgdorferi): 2017 case definition. Retrieved from: https://wwwn.cdc.gov/nndss/conditions/ lyme-disease/case-definition/2017.
Retrieved from: https://guidelines.moz.gov.ua/documents/2959.
Retrieved from: https://ru.wikipedia.org/wiki/%D0%91%D0%BE%D0%BB%D0%B5%D0%B7%D0%BD%D1%8C_%D0%9B%D0%B0%D0%B9%D0%BC%D0%B0.
Nyman, D., & Wahlberg, P. (2017). Lyme borreliosis (LB). EBM Guidelines. Retrieved from: https://www.ebm-guidelines.com/dtk/ebmaz/avaa?p_artikkeli=ebm00031
Stanek, G., Fingerle, V., Hunfeld, K.P., Jaulhac, B., Kaiser, R., Krause, A., ..., & Gray, J. (2011). Lyme borreliosis: Clinical case definitions for diagnosis and management in Europe. Clin. Microbiol. Infect., 17 (1), 69-79. DOI: https://doi.org/10.1111/j.1469-0691.2010.03175.x
Smiyan, S., Galaychuk, I., Zhulkevych, I., Nykolyuk, V., Komorovsky, R., Gusak, S., Bilozetsky, I. (2019). Sjögren’s syndrome and lymphadenopathy unraveling the diagnosis of Lyme diseas. Reumatologia, 57 (1), 59-62. Retrieved from: https://doi.org/10.5114/reum.2019.83242 DOI: https://doi.org/10.5114/reum.2019.83242
Galaychuk, I.Y., Zhulkevych, I.V., Smiyan, S.I., Nykolyuk, V.D., & Komorovsky, R.R. (2019). Boreliozna limfadenopatiia u praktytsi onkoloha (klinichni sposterezhennia). [Borrelious lymphadenopathy in oncology practice (clinical observations)]. Onkolohiia – Oncology, 21, 3. DOI: 10.32471/oncology.2663-7928.t-21-3-2019-g.7896. Retrieved from: URL: https://www.oncology.kiev.ua/article/7896/boreliozna-limfadenopatiya-u-praktici-onkologa-klinichni-sposterezhennya [in Ukrainian].
Lazynska, A.S., Kostyarkova, M.M., & Ivanova, S.M. (Eds.). (2010). Medical Microbiology Guide. Private medical Microbiology and etiologic diagnosis of infections. Book II/Col. The publishing house BYNOM.
Kopcha, V.S., Vasylieva, N.I., & Shkilna, M.I. (2016). Diahnostychni mozhlyvosti imunnoho blotynhu pry boreliozi [Diagnostic and immune blotting in case of borelioz]. Retrieved from: https://health-ua.com/article/6780-dagnostichn-mozhlivost-munnogo-blotingu-pri-boreloz.
Nykytyuk, S., Podobivsky, S.S., Klymnyuk, S.I., & Fedoniuk, L.Y. European Journal of Pediatrics, 178 (11), 1714-1714.
Nykytyuk, S., Klymnyuk, S., & Levenets, S. (2019). Laboratory diagnostics of lyme borreliosis in children with ticks bites in ternopil region. Georgian Medical News, 11 (296), 32-36.
