THE MEANING OF ENDOTHELIN IN THE CURRENT OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i2.8925Keywords:
endothelin-1, community-acquired pneumonia, endothelium, children, development of complications.Abstract
Introduction. In recent years, more and more attention has been paid to the role of microcirculation and endothelial dysfunction in the pathogenesis of many diseases, including pneumonia. Until now, the role of endothelin, as a marker of vascular endothelial damage, in the development of pneumonia in children, has not been studied.
The aim of the study – to learn the role of endothelin-1 in the course of community-acquired pneumonia in children and to establish the relationship between the level of this mediator in the blood with the severity of the course of pneumonia and the development of complications.
Material and Methods. 96 children aged 6 to 14 years old, patients with acute pancreatic pneumonia with different course of gravity were examined. The level of endothelin-1 in the blood was determined by the immuno-enzymatic method using a set of reagents "R & D", USA. Studies were conducted before and after treatment.
Results. There is a significant increase in the content of endothelin-1 in the blood of children suffering from generalized pneumonia of moderate severity and severe illness. The level of this indicator increases with the increase in the severity of the pathological process, with the level of endothelin before treatment exceeds the indexes of healthy subjects approximately 4 times in the group with the course of pneumonia of moderate severity and 6 times in the group with severe pneumonia. After treatment in the blood, high levels of endothelin levels are maintained, which can lead to microcirculatory disorders, hypoxia and increases the risk of chronizing the pathological process. It has been established that high endothelin-1 indices in the blood may increase the risk of severe purulent complications of community-acquired pneumonia.
Conclusion. In children suffering from community-acquired pneumonia, an increase in blood endothelin-1 levels has been observed. With an increase in the severity of the disease, the level of endothelin in the blood increases proportionally. Increasing the level of endothelin-1 in the blood may indicate a possible development of severe purulent complications of community-acquired pneumonia. After treatment of community-acquired pneumonia in children, high levels of endothelin in the blood remain in the blood, which can cause a chronic pathological process in the lungs.
References
Harris, M., Clark, J., & Coote, N. (2011). British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011. Thorax, 66, 1-23
UNICEF and WHO. (2006). Pneumonia: the forgotten killer of children. United Nations Children's Fund, World Health Organization, New York, NY.
Montejo Fernández, M., González Díaz, C., Mintegi Raso, S., Benito Fernández, J. (2005). Clinical and epidemiological study of community-acquired pneumonia in children aged less than 5 years old. An. Pediatr. (Barc), 63 (2), 131-136.
Fedortsiv, O.Ie., & Chornomydz, I.B. (2009). Stan endoteliiu sudyn u ditei, khvorykh na hostru pozalikarnianu pnevmoniiu [State of endothelium in children with acute community-acquired pneumonia]. Biomedical and Biosocial Anthropology, 12, 186-188 [in Ukrainian].
Pataraya, S.A., Preobrazhenskiy, A.V., & Sidorenko, B.A. (2000). Biokhimiya i fiziologiya semeystva endotelinov [Biochemistry and physiology of the endothelin family]. Kardiologiya – Cardiology, 6, 76-79 [in Russian].
Abidova, K.R. (1999). Znachenie endotelina-1 v regulyatsii funktsiy serdechno-sosudistoy sistemy [The importance of endothelin-1 in the regulation of cardiovascular functions]. Vrachebnoe delo – Doctor’s Business, 7-8, 22-27 [in Russian].
Gomazkov, O.A. (2001). Endotelin v kardiologii: molekulyarnye, fiziologicheskie i patologicheskie aspekty [Endothelin in cardiology: molecular, physiological and pathological aspects]. Kardiologiya – Cardiology, 2, 50-58 [in Russian].
Vizir, V.A., & Berezin, A.E. (2003). Rol endotelina-1 v progressirovanii serdechnoy nedostatochnosti [The role of endothelin-1 in the progression of heart failure]. Ukrainskyi medychnyi chasopys – Ukrainian Medical Journal, 3 (35), 5-16 [in Russian].
Treumova, S.І., & Boriak, V.P. (2014). Rol vazokonstryktornoi funktsii endoteliiu v patohenezi sertsevo-sudynnoi ta bronkholehenevoi patolohii [The role of vasoconstrictor endothelium function in pathogenesis of cardiovascular and bronchopulmonary pathology]. Visnyk problem biolohii i medytsyny – Journal of Problems of Biology and Medicine, 1 (106), 31-35 [in Ukrainian].
Lezhenko, H.O., Pashkova, O.Ie. (2013). Stan funktsii endoteliiu u ditei iz khronichnymy ta retsydyvnymy zakhvoriuvanniamy bronkholehenevoi systemy [Status of endothelial function in children with chronic and recurrent diseases of the bronchopulmonary system]. Bukovynskyi medychnyi visnyk – Bukovyna Medical Journal, 3 (67), 48-52 [in Ukrainian].
Yuldasheva, I.A. (2004). Sostoyanie endoteliya sosudov u bolnykh bronkhialnoy astmoy [The state of the vascular endothelium in patients with bronchial asthma]. Klinicheskaya meditsina – Clinical Medicine, 5, 36-38 [in Russian].
Fedortsiv, O.Ie., & Chornomydz, I.B. (2011). Diahnostychne znachennia vyznachennia markeriv endotelialnoi dysfunktsii v perebihu hostroi pozalikarnianoi pnevmonii u ditei [Diagnostic value of determination of markers of endothelial dysfunction in the course of acute community-acquired pneumonia in children]. Sovremennaya pediatriya – Modern Pediatrics, 1 (35), 127-129 [in Ukrainian].
Efimov, V.V., Blazhko, V.I., Voeykova, L.S., Krahmalova, E.O., Talalay, I.V., & Bondar, T.N. (2005). Pokazateli funktsii endoteliya u bolnykh KhOZL raznoy stepeni tyazhesti [Endothelial function in patients with COPD of varying severity]. Ukrainskyi pulmonolohichnyi zhurnal – Ukrainian Pulmonological Journal, 4, 44-47 [in Russian].
