COMPARATIVE CHARACTERISTIC OF OSTEOREGENERATION PROCESSES AT THE MATERIAL ON THE BASIS OF HYDROXYAPATITE AND POLYLACTIDE
DOI:
https://doi.org/10.11603/1811-2471.2017.v1.i3.8176Keywords:
bone defect, bone tissue regeneration, hydroxyapatite, polylactide, free oxyproline, protein synthesizing oxyproline.Abstract
Introduction. Bone regeneration in restoring bone defects of jaws is an important issue in modern dentistry.A large number of articles confirm that the ideal material does not exist yet and its search is relevant.The aim of the study. Study of osteorecreasing processes by evaluating collagen exchange markers and conducting a comparative analysis of reparation in correlation with X-ray data for 180 days of the experiment.
Materials and methods. The experiment was conducted on white male rats weighing 180-200 g. Under general anesthesia, animals created a through hole in the jaw area. In the control group, treatment was performed only with blood convection. In the experimental groups, the bone defect was replaced with a material based on hydroxyapatite and polyllactics with different percentages of components (1 group (80%: 20%) and 2nd group (50%: 50%)), and a separate group of intact animals that was subjected to urine sampling for comparative study.
X-ray examination of the removed jaws was carried out with the help of a digital radio-visualographer Intra (Finland).
Results and discussion. In all cases, after trauma, there are destruction processes that last up to 7 days. In the control group there is a slow reversal of their tendency, and balancing occurs only for 90 days, the achievement of physiological homeostasis - by 180 days.
In the 1 research group, the predominance of synthetic processes over destruction is noted for 30 days, and in the long term (90 and 180 days), the dominance of the process of catabolism over anabolism continues to prevail.
In the 2 experimental groups, the domination of collagen synthesis processes is accelerated and marked for 21 days, and the final completion of osteoreceptor is observed for 180 days.
The results of X-ray examinations correlated with the biochemical results of the study.
Conclusions The filling of bone defects by the proposed osteo implants changes the course of regeneration. It was established that filling the defect with a resorbable composite reduces destructive processes and accelerates the formation of the primary and secondary bone mosaic. In this respect, the composition with the same content of both its components was more effective.
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