HOMEOSTATIC DISORDERS IN PATIENTS WITH COMBINATION OF HYPERTONIC DISEASE AND CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i2.7661Keywords:
hypertonic disease, chronic pancreatitis, autonomic nervous system, heart rate variability, antioxidant system, kallikrein-kinin system, endogenous intoxicationAbstract
Introduction. Practically there are no diseases in the development and course of which autonomic nervous system did not play the role. This determines the relevance of research processes maintaining homeostasis with a combination of various diseases.
Target. The aim of this study was to examine and compare the character of vegetative, antioxidant, kallikrein-kinin system and parameters of endogenous intoxication disorders in the patients with combination of hypertonic disease (HD) and chronic pancreatitis (CP).
Materials and methods. The study involved 40 patients with HD and concomitant CP in non-remission phase, 15 healthy people. The middle-aged was (47,7±1,2) years. Research of autonomic regulation conducted by definition of standard statistical and spectral heart rate variability (HRV). Laboratory research of standard parameters of antioxidant, kallikrein-kinin systems and the severity of endogenous intoxication were conducted.
Results. Reduction of reducing total power spectrum, increasing the share of humoral-metabolic effects on heart rate, tendency to asympathicotonia autonomic reactivity, lower levels of superoxide dismutase, glutathione, prekallikrein, α2-macroglobulin, kininase II, higher levels of catalase, middle molecular peptides, total proteolytic activity of plasma kallikrein were observed in the patients with combination of hypertonic disease and chronic pancreatitis.
Conclusions. The signs of compensatory mechanisms disruption and increased autonomic nervous system imbalance with a decrease in ductility autonomous processes in the load were determined in patients with hypertonic disease upon accession the concomitant chronic pancreatitis. The combination of pathologies also accompanied by manifestations of endogenous intoxication, significant violations of antioxidant and kallikrein-kinin systems.
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