INDICATORS OF PROTEIN AND CARBOHYDRATE METABOLISM IN WHITE RATS CONSUMING DRINKING WATER WITH DIFFERENT CONTENTS OF SODIUM AND POTASSIUM IONS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i3.14082Keywords:
drinking water, sodium, potassium, effect on the body, protein and carbohydrate metabolism, ratsAbstract
SUMMARY. Various macro- and microelements can enter the body of consumers with drinking water. Their lack or excess can cause serious health problems. Such elements include sodium and potassium ions, which are very common in the environment and are one of the main ions in drinking water.
The aim – to evaluate the effect of drinking water with different sodium and potassium ion content on protein and carbohydrate metabolism in the body of white rats.
Material and Methods. The study was conducted on 72 white rats, divided into 6 groups of 12 individuals each, which differed among themselves in the quality of drinking water. The 1st group was the control group. Animals of the 2nd group consumed water with the content of Na+ ions at a concentration of 100.0 mg/l, of the 3rd group – with K+ ions at a concentration of 10.0 mg/l, of the 4th group – with the addition of Na+ at a concentration of 100, 0 mg/l and K+ 10.0 mg/l, the 5th – respectively Na+ 50.0 mg/l and K+ 5.0 mg/l, the 6th – Na+ 25.0 and K+ 2.5 mg/l. On the 15th and 30th day from the beginning of the experiment, the level of total protein, urea, creatinine, glucose and pyruvic acid was determined in the blood serum using a semi-automatic biochemical analyzer "Humalyzer 2000".
Results. Consumption of drinking water with potassium ions at a concentration of 10.0 mg/l and sodium ions at a concentration of 100.0 mg/l both isolated and in combination causes significant changes in the content of total protein, creatinine, urea and glucose in the blood serum of rats as per 15 and on the 30th day of the experiment. The most pronounced hyperglycemia occurs when using a water-salt solution with a concentration of sodium ions of 100.0 mg/l. Reducing the concentrations of both ions to 25.0 mg/l (sodium) and 2.5 mg/l (potassium) in drinking water did not cause changes in the indicators of protein and carbohydrate metabolism in the animals.
Conclusions. Drinking water with different content of sodium and potassium ions has a negative effect on the body of rats, causing changes in protein and carbohydrate metabolism. The intensity of changes depended on the concentration of ions in drinking water and the duration of its use.
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