PREDICTION OF HORMONAL DISORDERS LEADING TO ADVERSE REPRODUCTIVE PROGNOSIS IN YOUNG WOMEN WITH AUTOIMMUNE THYROIDITIS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i2.13900Keywords:
infertility, prognosis, autoimmune thyroiditis, hypothyroidism, mathematical model, 25(ОН)D, reproductive ageAbstract
SUMMARY. The conditions of modern society require the creation of a clear diagnostic algorithm that will allow to quickly and accurately identify women of high risk groups for the occurrence and progression of hormonal disorders against the background of autoimmune thyroiditis, which will affect the unfavorable reproductive prognosis.
The aim – to create a mathematical model for predicting hormonal disorders in women of reproductive age against the background of autoimmune thyroiditis, which contribute to a negative reproductive prognosis.
Material and Methods. We examined 147 women of reproductive age (average age 33±1.87) with autoimmune thyroiditis. All patients underwent a comprehensive clinical and laboratory examination. Multiple regression analysis was used to construct a prognostic model of hormonal disturbances in women with autoimmune thyroiditis. The statistical package Statistica 10.0 and the spreadsheet editor Microsoft Excel 2007 were used for statistical processing.
Results. 11 reliable factors were identified, which included: age, TSH, ATPO, ATTH, 25(OH)D, AMH, LDL, HDL, smoking, anxiety and depressive syndrome, for predicting hormonal disorders in autoimmune thyroiditis, which contribute to an unfavorable reproductive prognosis in young women, and a mathematical model, a histogram of residual deviations, and a scatter diagram of the residuals were constructed.
Conclusions. The mathematical model for predicting hormonal disorders in autoimmune thyroiditis, which leads to an unfavorable reproductive prognosis, is qualitative and informative. The use of this model in clinical practice will allow timely identification of a group of women with a high risk of progression of hormonal disorders against the background of a disease that negatively affects reproductive function.
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