PREDICTION OF HORMONAL DISORDERS LEADING TO ADVERSE REPRODUCTIVE PROGNOSIS IN YOUNG WOMEN WITH AUTOIMMUNE THYROIDITIS
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i2.13900Keywords:
infertility, prognosis, autoimmune thyroiditis, hypothyroidism, mathematical model, 25(ОН)D, reproductive ageAbstract
SUMMARY. The conditions of modern society require the creation of a clear diagnostic algorithm that will allow to quickly and accurately identify women of high risk groups for the occurrence and progression of hormonal disorders against the background of autoimmune thyroiditis, which will affect the unfavorable reproductive prognosis.
The aim – to create a mathematical model for predicting hormonal disorders in women of reproductive age against the background of autoimmune thyroiditis, which contribute to a negative reproductive prognosis.
Material and Methods. We examined 147 women of reproductive age (average age 33±1.87) with autoimmune thyroiditis. All patients underwent a comprehensive clinical and laboratory examination. Multiple regression analysis was used to construct a prognostic model of hormonal disturbances in women with autoimmune thyroiditis. The statistical package Statistica 10.0 and the spreadsheet editor Microsoft Excel 2007 were used for statistical processing.
Results. 11 reliable factors were identified, which included: age, TSH, ATPO, ATTH, 25(OH)D, AMH, LDL, HDL, smoking, anxiety and depressive syndrome, for predicting hormonal disorders in autoimmune thyroiditis, which contribute to an unfavorable reproductive prognosis in young women, and a mathematical model, a histogram of residual deviations, and a scatter diagram of the residuals were constructed.
Conclusions. The mathematical model for predicting hormonal disorders in autoimmune thyroiditis, which leads to an unfavorable reproductive prognosis, is qualitative and informative. The use of this model in clinical practice will allow timely identification of a group of women with a high risk of progression of hormonal disorders against the background of a disease that negatively affects reproductive function.
References
Yuzko, O.M. (2016). Dopomizhni reproduktyvni tekhnolohii Ukrainy – 25 rokiv uspikhu [Assisted reproductive technologies of Ukraine - 25 years of success]. Asotsiatsii akusheriv-hinekolohiv Ukrainy – Association of Obstetricians and Gynecologists of Ukraine, 2(38), 393-395 [in Ukrainian].
Dorofieieva, U.S., & Boichuk, O.H. (2020). Suchasni pohliady na nepliddia zhinok starshoho reproduktyvnoho viku (ohliad literatury) [Modern views on infertility of women of older reproductive age (literature review)]. Aktualni pytannia pediatrii, akusherstva ta hinekolohii – Current Issues of Pediatrics, Obstetrics and Gynecology, 1, 74-79. ISSN 2411 4944 [in Ukrainian].
Feskov, V.O. (2017). Suchasni pidkhody do likuvannia bezpliddia u zhinok, khvorykh na endometrioz yaiechnykiv, z vykorystanniam ekstrakorporalnoho zaplidnennia [Modern approaches to the treatment of infertility in women with ovarian endometriosis, using in vitro fertilization]. Scientific Journal “ScienceRise: Medical Science”, 7(15), 39-43. DOI: 10.15587/2519-4798.2017.107739 [in Ukrainian].
Pasyechko, N.V., Kulchynska, V.M., Naumova, L.V., Krytskyi, T.I., & Yevstratieva, Yu.V. (2020). Subklinichnyi hipotyreoz u zhinok na etapi pryrodnoho planuvannia vahitnosti ta iz vykorystanniam dopomizhnykh reproduktyvnykh tekhnolohii [Subclinical hypothyroidism in women at the stage of natural pregnancy planning and with the use of assisted reproductive technologies]. Klinichna endokrynolohiia ta endokrynna khirurhiia – Clinical Endocrinology and Endocrine Surgery, 4(72), 70-77. DOI: 10.30978/CEES-2020-4-70 [in Ukrainian].
Pasyechko, N.V., Kulchinska, V.M., & Naumova, L.V. (2020). Subklinichnyy hipotyreoz u vahitnykh v yododefitsytnomu rehioni: likuvaty chy ni? [Subclinical hypothyroidism in pregnant women in an iodine-deficient region: to treat or not?]. Mizhnarodnyy endokrynolohichnyy zhurnal – International Journal of Endocrinology, 6(16), 41-48. DOI: 10.22141/2224-0721.16.6.2020.215385 [in Ukrainian].
Bachynska, I.V. (2016). Stanovlennia menstrualnoi funktsii ta hormonalnyi homeostaz divchat-pidlitkiv, khvorykh na avtoimunnyi tyreoidyt [Development of menstrual function and hormonal homeostasis in adolescent girls with autoimmune thyroiditis]. Reproduktivnaia endokrinologiia – Reproductive Endocrinology, 5, 60-64. DOI: 10.18370/2309-4117.2016.31.60-64 [in Ukrainian].
Krassas, G.E., Poppe, K., & Glinoer, D. (2010). Thyroid function and human reproductive health. Endocr. Rev., 31(5), 702-755. DOI: 10.1210/er.2009-0041.
Marcela Salazar-Viedma, Juan Gabriel Vergaño-Salazar, Luis Pastenes, & Vivian D’Afonseca (2021). Simulation Model for Hashimoto Autoimmune Thyroiditis Disease. Endocrinology, 162(12). DOI: 10.1210/endocr/bqab190.
Boya, Yang, X, Tang, Haller Michael J., Desmond, A. Schatz, Libin, Rong (2021). A unified mathematical model of thyroid hormone regulation and implication for personalized treatment of thyroid disorders. Journal of Theoretical Biology, 528. DOI: 10.1016/j.jtbi.2021.110853.
Balamurugan, Pandiyan. (2019). Mathematical Modeling of Thyroid Size and Hypothyroidism in Hashimoto’s Thyroiditis. Goiter. Causes and Treatment. DOI: 10.5772/intechopen.90481.
