STATE OF THE ENDOTHELIUM IN PATIENTS WITH ARTERIAL HYPERTENSION AND REDUCED THYROID GLAND FUNCTION
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i2.13898Keywords:
endothelial dysfunction, endothelium-dependent vasodilation, arterial hypertension, primary hypothyroidism, subclinical hypothyroidismAbstract
SUMMARY. Endothelial dysfunction is considered a key link in the development of cardio-vascular diseases, in most cases it precedes and accompanies arterial hypertension and is considered a marker of cardio-vascular disorders in patients with diabetes and metabolic syndrome. Insufficient data is present about the state of endothelium in patients with thyroid hypofunction.
The aim – to determine the functional state of endothelium in patients with arterial hypertension and decreased thyroid function by means of brachial artery ultrasound examination.
Material and Methods. 99 patients who were undergoing treatment in cardiological department of Ternopil Regional Clinical Hospital took part in the study. 65 of them were diagnosed hypothyroidism (whether subclinical or primary). All examinees underwent a cuff test. By using ultrasound doppler the initial diameter of brachial artery, peak systolic and end-diastolic blood flow velocities were determined, brachial artery diameter 5 minutes after distal blood flow occlusion and 90 seconds after relaxation. Endothelium-dependent vasodilation was estimated as the ratio of the difference between the diameter during the test and the diameter at rest to the diameter at rest in %.
Results. Disruption of normal endothelial function was reported among 93 (93.94 %) patients with arterial hypertension – mean endothelium-dependent vasodilation was 6.70±0.08 %. More pronounced manifestations were observed in patients with reduced thyroid function compared to patients with arterial hypertension and retained thyroid function. Even so, the endothelium-dependent vasodilation indicator was worse in the group of patients with subclinical hypothyroidism compared to patients with primary hypothyroidism – 5.91±0.05 % and 6.77±0.10 % respectively.
Conclusions. The identified changes evidence the necessity of thyroid function compensation among both – patients with subclinical and primary hypothyroidism in order to access optimal effect in the correction of endothelial dysfunction.
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