PLACENTAL DYSFUNCTION AS A FACTOR IN THE COMPLICATED COURSE OF PREGNANCY: FROM THEORY TO PRACTICE

Abstract

SUMMARY. Modern view of the role of placental dysfunction in the development of pregnancy complications has not only theoretical but also great practical significance. Management during pregnancy should be directed both in support of the placenta functions throughout the period of gestation and to search for sensitive methods of early diagnosis and forecasting the course of the pathological process. From this point of view, great interest represents the study of intracellular energy metabolism processes in the conditions of physiological and pathological placentalogenesis and the possibilities of bioregulating correction of obstetric pathology.

The aim – to assess the effectiveness of the use of metabolic therapy in pregnant women with placenta dysfunction. Based on cytochemical studies of mitochondrial status of lymphocytes.

Material and Methods. 60 women with a pregnancy in the term of 22–28 weeks were examined. The 1^st group – pregnant women with the physiological course of pregnancy (control group) – 20 patients; the 2^nd group is pregnant women with placenta dysfunction, who received standard metabolic therapy – 20 patients; the 3^rd group – pregnant women with placenta dysfunction, for whom bioregulative correction drugs “Heel” were prescribed – 20 patients. All pregnant women were conducted by a complete clinical and laboratory examination before and after the end of the research. Patients of the 2^nd group received standard metabolic therapy that included L-arginine preparations. Respondents of the 3^rd group received treatment with “Ovarium compositum”, “Coenzyme compsitum” and “Ubiquinone compositum” during 10 days.

Results. The results of the study showed a positive therapeutic picture in the main groups of pregnant women with placental dysfunction, but the results of mitochondrial imbalance showed the restoration of energy metabolism in key parameters only in patients receiving complex therapy with bioregulatory drugs “Heel” and therefore, the prognosis for a successful pregnancy in those women was really higher.

Conclusions. Thus, cytochemical assessment of the energy supply of cells can be used as an effective tool for diagnosing and predicting complications of pregnancy in placental dysfunction. The appointment of bioregulatory drugs in the complex treatment of pregnant women at risk of obstetric pathology on the background of placental insufficiency allows to expand the panel of effective therapeutic management.