QUANTITATIVE MORPHOLOGICAL ASPECTS OF STUDY OF FEATURES OF STRUCTURAL RESTRUCTURE OF VESSELS OF HEMOMICROCIRCULATOR BED OF VENTRICES OF HEART IN CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i1.12991Keywords:
postresection portal hypertension, ventricles, hemomicrocirculatory bedAbstract
SUMMARY. Removal of significant volumes of liver parenchyma is complicated by the development of postresection portal hypertension, bleeding from varicose veins of the esophagus, stomach, rectum, splenomegaly, ascites, parenchymal jaundice, portosystemic encephalopathy, polyorgan failure.
The aim – to study the peculiarities of structural rearrangement of vessels of hemomicrocirculatory bed in postresection portal hypertension by quantitative morphological methods.
Material and Methods. The hemomicrocirculatory bed of the ventricles of 67 white male rats, which were divided into 3 groups, was morphometrically studied. The 1-st group consisted of 20 intact animals, the 2-nd – 30 rats with postresection portal hypertension, the 3-rd – 17 animals with postresection portal hypertension and multiorgan failure. Euthanasia of experimental animals was performed by bloodletting under thiopental anesthesia 30 days after the start of the experiment. The vascular bed of the heart was filled with mascara-gelatin mixture. Histological micropreparations were made from the ventricles of the heart, which determined the diameters of arterioles, precapillary arterioles, hemocapillaries, capillary venules, venules, microvascular density. Quantitative indicators were processed statistically.
Results. Postresection portal hypertension was complicated by severe remodeling of vessels of the hemomicrocirculatory bed, which was characterized by narrowing of arterioles, precapillary arterioles, dilation of capillary venules, venules, decreased microvascular density. Changes in hemomicrocirculation lead to venous hyperemia, hypoxia, dystrophy, necrobiosis of cardiomyocytes, endothelial cells, stromal structures, foci of infiltration, cardiosclerosis with their predominance in the left ventricle with the development of multiple organ failure.
Conclusions. Postresection portal hypertension leads to a pronounced structural rearrangement of the hemomicrocirculatory bed of the ventricles of the heart, which is characterized by severe narrowing of arterioles, precapillary arterioles, metabolic (hemocapilillary) link, expansion of capillary venules and venules, stromal structures, infiltrative and sclerotic processes that predominate in the left ventricle and in the combination of postresection portal hypertension with multiorgan failure.
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