ANALYSIS OF THE INTERCONNECTIONS OF THE PANCREAS FUNCTIONAL CAPACITY WITH THE PARAMETERS OF ENDOTOXICOSIS, PRO- AND ANTIOXIDANT STATUS IN CHRONIC PANCREATITIS, DEPENDING ON THE PRESENCE OF COMORBIDITY WITH DIABETES MELLITUS TYPE 2
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i1.12984Keywords:
chronic pancreatitis, type 2 diabetes, endotoxicosis, lipid peroxidationAbstract
SUMMARY. Excessive amounts of endogenous toxins and other aggressive oxidants disrupt the physicochemical properties of cell membranes, opening access to a number of damaging agents, which can complicate the course of chronic pancreatitis, especially in comorbidity with type 2 diabetes.
The aim – to conduct a comparative analysis of the relationship between pancreatic function in patients with isolated chronic pancreatitis and such in combination with type 2 diabetes mellitus with parameters of endotoxicosis, lipid peroxidation, enzymatic, and non-enzymatic antioxidant defense systems.
Material and Methods. 137 patients with exacerbation of chronic pancreatitis, which in 112 cases was combined with type 2 diabetes, were examined, and 25 patients had isolated chronic pancreatitis to study the complicating effects of type 2 diabetes. The excretory function of the pancreas was studied by determining fecal α-elastase, incretory function – by fasting blood glucose, to assess insulin resistance – IP index HOMA-IR.
Results. Even in the remission phase of chronic pancreatitis, the presence of active endogenous intoxication and lipid peroxidation was proved, which was significantly more significant in the comorbidity of chronic pancreatitis with type 2 diabetes mellitus, as well as weakening of enzymatic and non-enzymatic protection.
Conclusion. The data showed the presence of inflammation, endotoxicosis and lipid peroxidation with concomitant deficiency of antioxidant protection, which can be explained by the long course of chronic pancreatitis and comorbidity of chronic pancreatitis and type 2 diabetes mellitus, which is the cause and effect of trophological insufficiency.
References
Dominguez-Munoz, J.E., Lucendo, A., Carballo, L.F., Iglesias-Garcia, J., & Tenias, J.M. (2014). A Spanish multicenter study to estimate the prevalence and incidence of chronic pancreatitis and its complications. Rev. Esp. Enferm. Dig., 106(4), 239-245.
Fang, M. (2020). Trends in Diabetes Management Among US Adults: 1999–2016. J. General Intern. Med., 35(5), 1427-1434.
Babinets, L.S., Sasyk, H.M., Halabitska, I.M., & Mykuliak, V.R. (2021). Possibilities of complex rehabilitation of patients with type 2 diabetes and concomitant chronic pancreatitis in ambulatory practice. Balneologia, 1, 12-15.
Babinets, L.S., Shevchenko, N.A., Sasyk, H.M., & Zemlyak, O.S. (2017). Research of lipid exchange diffusion of medium-age patients with chronic pancreatitis with diabetes mellitus. J. Educ., Health and Sport., 7(11), 309-318.
Babinets, L.S., Halabitska, I.M., & Mayevska, T.H. (2017). Zovnishnosekretorna nedostatnist pidshlunkovoyi zalozy ta dysbalans systemy prooksydanty–antyoksydanty pry pervynnomu osteoartrozi z komorbidnymy stanamy [Exocrine insufficiency of the pancreas and imbalance of the prooxidant-antioxidant system in primary osteoarthritis with comorbid conditions]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 1(3), 22-25. DOI: 10.11603/1811-2471.2017.v1.i3.8099 [in Ukrainian].
Bellin, M.D., Whitcomb, D.C., Abberbock, J., Sherman, S., Sandhu, B.S., Gardner, T.B., ..., & Yadav, D. (2017). Patient and disease characteristics associated with the presence of diabetes mellitus in adults with chronic pancreatitis in the United States. Am. J. Gastroenterol., 112(9), 1457-1465.
Bhardwaj, P., Garg, P.K., Maulik, S.K., Saraya, A., Tandon, R.K., & Acharya, S.K. (2009). A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. Gastroenterology, 136(l), 149-159. DOI: 10.1053/j.gastro.2008.09.028.
Bhardwaj, P., & Yadav, R.K. (2013). Chronic pancreatitis: role of oxidative stress and antioxidants. Free Radic. Res., 47(l l), 941-949. DOI: 10.3109/10715762.2013.804624.
Bian, Y., Wang, L., Chen, C., Lu, J.P., Fan, J.B., Chen, S.Y., & Zhao, B.H. (2013). Quantification of pancreatic exocrine function of chronic pancreatitis with secretin-enhanced MRCP. World J. Gastroenterol., 19(41), 7177-7182. DOI: 10.3748/wjg.vl9.i41.7177.
Bitton, S., & Pettei, M.J. (2016). Exocrine pancreatic insufficiency. Pediatr. Rev., 37(2), 85-87. DOI: 10.1542/pir.2015-0084.
Capurso, G., Traini, M., Piciucchi, M., Signoretti, M., & Arcidiacono, P.G. (2019). Exocrine pancreatic insufficiency: prevalence, diagnosis, and management. Clin. Exp. Gastroenterol., 12, 129-139. DOI: 10.2147/CEG.S168266.
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